+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Detection of Toxoplasma gondii in immunodeficient subjects by gene amplification: influence of therapeutics

, : Detection of Toxoplasma gondii in immunodeficient subjects by gene amplification: influence of therapeutics. Scandinavian Journal of Infectious Diseases 28(4): 383-386

Polymerase chain reaction (PCR) technology was used to detect Toxoplasma gondii DNA in 253 immunodeficient subjects, 179 of whom were infected with the human immunodeficiency virus (HIV). The incidence of toxoplasmosis was 12.3% (22/179) in the HIV-infected subjects and 2.7% (2/74) in the remainder. The sensitivity of the PCR during episodes of toxoplasmosis in HIV-infected subjects not on antiparasitic treatment was 86.6% on peripheral blood and 60% on cerebrospinal fluid (CSF), but was only 25% and 16.7%, respectively, in subjects receiving specific treatment or prophylaxis against Pneumocystis carinii. Among the HIV-seronegative population, six patients undergoing anticancer chemotherapy were PCR positive on bronchoalveolar lavage fluid but did not develop pulmonary toxoplasmosis, suggesting transient carriage.


PMID: 8893403

DOI: 10.3109/00365549609037924

Other references

Cheema, T.A.; Ward, C.E.; Fisher, S.K., 2005: Subnanomolar concentrations of thrombin enhance the volume-sensitive efflux of taurine from human 1321N1 astrocytoma cells. The ability of subnanomolar concentrations of thrombin to protect both neurons and glia from ischemia and other metabolic insults has recently been reported. In this study, we demonstrate an additional neuroprotective property of thrombin; its abi...

Verghese, A.; Mattingley, J.B.; Palmer, P.E.; Dux, P.E., 2017: From eyes to hands: Transfer of learning in the Simon task across motor effectors. Inhibition of irrelevant and conflicting information and responses is crucial for goal-directed behaviour and adaptive functioning. In the Simon task, for example, responses are slowed if their mappings are spatially incongruent with stimuli that...

Katayama, R.; Wakitani, S.; Tsumaki, N.; Morita, Y.; Matsushita, I.; Gejo, R.; Kimura, T., 2004: Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow. Objective. Cartilage-derived morphogenetic protein 1 (CDMP1), which is a member of the transforming growth factor-beta superfamily, is an essential molecule for the aggregation of mesenchymal cells and acceleration of chondrocyte differentiation....

Mason, E.H., 1928: The Occurrence of a Raised Basal Metabolic Rate in New Growth without Hyperthyroidism. A case of melano-sarcoma with extensive involvement of the liver which had a consistently elevated basal metabolic rate is reported. The increased O consumption was independent of any alteration in the pulse rate. There was no evidence of thyroid...

Craig Klauber; Andrew Parker; Wilhelm van Bronswijk; Helen Watling, 2001: Sulphur speciation of leached chalcopyrite surfaces as determined by X-ray photoelectron spectroscopy. A key factor in improving the bioleaching route for chalcopyrite processing is a better understanding of the surface speciation that exists under chemical leaching conditions that mimic the acid bioleach. The surface sulphur speciation of chalcopy...

Yu, W.X., 1980: Quantitative diagnosis of trophoblastic cell diseases. Zhonghua Fu Chan Ke Za Zhi 15(3): 173-175

Ovchinnikov, Y.L.; Bartenev, V.D., 1987: Results of testing an experimental activator of a machine for berries harvesting. Improving the design of the shaking mechanism of soft fruit harvesters was found to be the best method of increasing the throughput and quality of work. Results are presented of laboratory and field investigations to assess the performance of a so...

Fisher, A.Scarbrough., 2015: What should you do if you received a 4-5-320(c) notification letter from the Tennessee Department of Health?. Tennessee Nurse 78(2): 10-10

Krishnamurthy S., 1974: Puberty attainment in slaughter weight gilts in relation to month examined. Journal Of Animal Science: 160

Liang, X.; Mochizuki, T.; Nishioka, H.; Asanuma, H., 2010: Line up base pairs and intercalators one by one in a stable duplex. A stable double helix involving alternating base pairs and azobenzene moieties was constructed. In this supramolecule, base pairs and azobenzenes are lined up one by one to form an interstrand-wedged motif: each base pair is sandwiched with two az...