+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Differential and constitutive expression of the DRB1 and DRA gene products controls the surface HLA-DR expression level in human eosinophilic leukaemia cell lines

, : Differential and constitutive expression of the DRB1 and DRA gene products controls the surface HLA-DR expression level in human eosinophilic leukaemia cell lines. Cell Structure and Function 22(1): 15-20

Use of 2-D gel and imaging plate analysis enabled biosynthetically radiolabeled immunoprecipitates to be quantitated at the very low level of gene products during processing from RER inside cells to cell surface. We used this efficient and sensitive measurement to analyse expression of HLA-DR molecules in human eosinophilic leukaemia cell lines. We found that they synthesized a constitutive amount of DRA gene products and differential amounts of DRB1 gene products. Thus, the incompletely inducible expression of DRB1 gene products was responsible for the limited accumulation of normally assembled molecules for cell surface expression and the lack of serological determination.


PMID: 9113385

Other references

Bilteanu, G.C.stache, D., 1976: Soybeans, an important source of proteins and oil. Productia vegetala: 28 (2) 25-29

Wickes A.D.; Howell S.B., 1985: Pharmacokinetics of hexamethylmelamine administered via the intraperitoneal route in an oil emulsion vehicle. Ovarian carcinomas remain localized to the peritoneal cavity throughout most of their natural history. Pharmacokinetic modeling has suggested that intracavitary administration of chemotherapeutic agents by peritoneal dialysis may result in a much...

Zhao, X.; He, M.; Wan, D.; Ye, Y.; He, Y.; Han, L.; Guo, M.; Huang, Y.; Qin, W.; Wang, M.W.i; Chong, W.; Chen, J.; Zhang, L.; Yang, N.; Xu, B.; Wu, M.; Zuo, L.; Gu, J., 2003: The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis. Hepatocellular carcinoma (HCC) is one of the most common human cancers in Asia. Previous studies have shown that in addition to aberrations of the p53 gene on chromosome 17p13.1, other gene(s) on chromosome 17p13.3 may also play a role in HCC. To...

Li, L.Zhen, 1996: Occurrence of Ischnosoma splendidum in Japan with description of its diagnoses. Holarctic staphilynid beetle, Ischnosoma splendidum (Gravenhorst), was firstly recorded from Hokkaido, Japan. The male diagnoses are described and illustrated.

Sadoff, H.L., 1970: Symposium on bacterial spores: X. Heat resistance of spore enzymes. Journal of Applied Bacteriology 33(1): 130-140

Yang ChiKun, 1993: Silvius cordicallus Chen et Quo new to Guizhou Province (Diptera: Tabanidae). Silvius cordicallus is newly recorded from Guizhou Province, China.

Ru, I.; Cang, H.; Hu, C.; Hu, Y., 2013: Comparison of two surgical methods for aseptic nonunions of femoral shaft orthopaedic surgery. To compare the outcomes between intramedullary nail change and augmentation plating with a retained intramedullary nail for aseptic nonunion of femoral shaft fractures after femoral nailing, and to analyze the cause so as to guide the clinical app...

Nakamura, K.; Takayama, K.; Nagai, T.; Maitani, Y., 2003: Regional intestinal absorption of FITC-dextran 4,400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats. Nanoparticles (NP) are potential carriers for drug delivery to the targeted intestine. NP based on beta-sitosterol beta-D-glucoside (Sit-G) enhanced the colon-specific absorption of FITC-dextran 4,400 (FD-4), because the concentration-dependent in...

Zamlauski-Tucker, M.J.; Springate, J.E.; Van Liew, J.B.; Noble, B.; Feld, L.G., 1992: Glomerular function in spontaneously diabetic rats. This study was undertaken to determine whether hyperfiltration exists at the single nephron level and whether albumin excretion is increased early in the course of diabetes in Biobreeding rats. Diabetic rats were studied at 8-12 weeks after the on...

Amtmann, E.; Sauer, G., 1982: Activation of non-expressed bovine papilloma virus genomes by tumour promoters. Nature 296(5858): 675-677