geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Differential responses of human papillary and reticular fibroblasts to growth factors


, : Differential responses of human papillary and reticular fibroblasts to growth factors. American Journal of the Medical Sciences 305(4): 203-207

Differences in the responses to growth factors of normal fibroblasts and scleroderma fibroblasts have been demonstrated previously. Because human dermal fibroblasts are heterogeneous populations, whether known differences between papillary and reticular dermal fibroblasts could account for the noted differences between normal and scleroderma fibroblasts was investigated. Papillary dermal fibroblasts were grown from a dermatome section of normal skin from an adult donor. Reticular dermal fibroblasts were cultured from punch biopsy specimens taken from the same location. In vitro, papillary dermal fibroblasts proliferated more rapidly, had a higher mitotic index and reached greater density at confluence, confirming previous observations. The reticular dermal fibroblasts were more dendritic. Reticular dermal fibroblasts had higher rates of tritiated thymidine uptake and larger increases in mitotic index in response to isoforms of platelet-derived growth factor (PDGF). The characteristic response of scleroderma fibroblasts, potentiation of the mitogenicity of PDGF AA by transforming growth factor-beta (TGF-beta), was not observed in either cell type. Therefore, the phenotypic characteristics of scleroderma fibroblasts cannot be explained by an unusual admixture of papillary and reticular fibroblasts.

US$29.90

PMID: 8475944


Other references

Wepf, R.; Gross, M., 1987: Role of high thoracic sympathetic neurotomy in the treatment of migraine. Apropos of 125 cases. Revue Medicale de la Suisse Romande 107(5): 427-431

Bal, M.; Atar, Y.; Salturk, Z.; Ateş, A.Hakan.; Yağcı, S.; Coşkun Bal, Gökçen., 2013: Lingual Haematoma due to Tenecteplase in a Patient with Acute Myocardial Infarction. The use of intravenous thrombolytic agents has revolutionised the treatment of acute myocardial infarction. However, the improvement in mortality rate achieved with these drugs is tempered by the risk of serious bleeding complications, including i...

Knerich, R.; Adinolfi, D.; Silvani, V.; Robustelli della Cuna, G.; Spanu, G.; Preti, P.; Rodriguez y Baena, R., 1984: Chemotherapy and immunotherapy of intracranial malignant gliomas. Although in recent years a great attempt has been made in brain tumor chemotherapy, this therapeutic approach appears to be conditioned by a large number of problems such as cell kinetics, tumor growth modalities, and drug delivery. Therefore only...

Wetherall, A.P.; Howell, G.P., 1992: Assessment of the use of disposable skin staplers to reduce laparotomy time in penetrating ballistic injury of the abdomen. Annals of the Royal College of Surgeons of England 74(3): 228-228

Komatsu, Yukio, 1993: Long-term potentiation in developing visual cortex. Long-term potentiation (LTP) may be one of the synaptic mechanisms underlying the experience-dependent modification of neuronal responses in visual cortex, since LTP in cat visual cortex is most easily induced during the sensitive period when visu...

Wilson, W.L., 1973: Multidirectional orthodontic treatment. Transactions. European Orthodontic Society: 223-229

Bade, N.; Chhaparwal, B.C.; Singh, S.D.; Pohowalla, J.N., 1972: Evaluation of B.C.G. and small-pox vaccination in neonates. Indian Pediatrics 9(12): 762-766

Imai, M.; Chang, K.S.; Tanz, R.D.; Stevens, W.C.; Kemmotsu, O., 1991: Enhanced myocardial depression from bupivacaine in diabetic rats. We examined the direct effects of bupivacaine on the diabetic rat myocardium using an isolated perfused (Langendorff) heart preparation. Rats were made diabetic by injection of streptozotocin (55 mg.kg-1, i. v.). 12 weeks after the administration...

Knizek Jan Otto; Fetter Hans, 1950: High-alumina refractories and the genesis, occurrence and uses of alunite, 1 of The refractory properties of alunite. Transactions and Journal of the British Ceramic Society 49(5): 202-223

Kalliola R.; Salo J.; Puhakka M.; Rajasilta M.; Hame T.; Neller R.J.; Rasanen M.E.; Danjoy Arias W.A., 1992: Upper amazon channel migration implications for vegetation perturbance and succession using bitemporal landsat mss images. Naturwissenschaften 79(2): 75-79