geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Differential sensitivity of various temporal lobe structures in the rat to kindling and status epilepticus induction


, : Differential sensitivity of various temporal lobe structures in the rat to kindling and status epilepticus induction. Epilepsy Research. 23(3): 179-187

Using focal brain stimulation (kindling), discrete seizures can be triggered from many neuroanatomic sites with varying degrees of facility. From several of these sites, protracted seizures or status epilepticus (SE) also can be triggered. To date, no comparison has been made between different brain sites in their sensitivity both to kindling and to SE development. In this report, we have compared the kindling profiles of three amygdala nuclei, namely the basal (BL), central (CE), and medial (ME) nuclei, to the adjacent piriform (PIR) and perirhinal (PRH) cortices. In addition, three weeks following kindling, the susceptibility of each kindled site to status epilepticus (SE) was assessed by exposing the site to 60 min of electrical stimulation. We observed that (a) during the course of daily kindling, the afterdischarge threshold dropped progressively and significantly in all structures, (b) the rate of kindling in the PRH and PIR cortices and the CE amygdala was significantly faster than either the BL or ME amygdala, (c) when discrete convulsions were triggered, the latency to forelimb clonus in the PRH cortex and CE amygdala was significantly shorter than the other three structures, and (d) despite being slower to kindle than most other sites, stimulation of the BL nucleus most readily triggered SE. The kindling data suggest that discharges triggered from the PRH and CE more readily access motor systems supporting limbic convulsions than discharges triggered from the BL, ME nuclei or the PIR cortex. On the other hand, the SE data indicate that the mechanisms and circuits associated with the development of discrete kindled seizures are not identical to those associated with the induction of limbic SE.

US$19.90

PMID: 8739121

DOI: 10.1016/0920-1211(95)00084-4


Other references

Silva A.M.D.; Fialho S.A.G.; Schoenau L.S.F., 1991: The use of dynamic compression plates for the internal fixation of transverse diaphyseal osteotomies of the tibia in dogs. The use of dyanmic compression plates for internal fixation of transverse diaphyseal osteotomies of the tibia was studied in four adult dogs. Early return to normal function of the injured limb was achieved in the first or second week of the posto...

Mironov, N.A.; Soskin, I.M., 1990: A fatal case of amebic dysentery. The paper describes a case of complicated amebic dysentery imported from India in a 39-year old man. Even in microscopic examination of feces, amebiasis diagnosis presented difficulties for clinicists.

Pribram K.H., 1973: The case for a brain electro diagnostic in functional disorders. Bogoch, Samuel (Ed ) Biological Diagnosis Of Brain Disorders The Future Of The Brain Sciences Proceedings Of The 5th International Conference New York, N Y , U S A , Oct 2-3, 1972 Xii+392p Illus Spectrum Publications, Inc : Flushing, N Y , U S A Isbn 0-470-08600-9 61-73

James, B.R.; Bartlett, R.J., 1983: Behavior of chromium in soils: VII. Adsorption and reduction of hexavalent forms. Based on adsorption studies with Fe(OH)3, Cr(OH)3, and soils, 10 mM K-phosphate buffered at pH 7.2 was found to be adequate for characterizing exchangeable Cr(VI). The quantity of Cr(VI) removed from solution by 19 A and 19 B horizon soils from th...

Berger, F.G.; Breen, G.A.M.; Paigen, K., 1979: Genetic determination of the developmental program for mouse liver beta galactosidase ec 3.2.1.23 involvement of sites proximate to and distant from the structural gene. The identification and mode of action of genetic loci that program gene expression during development are important for understanding differentiation in higher organisms. The following 2 patterns for the postnatal development of liver .beta.-galac...

Peccarisi, C.; Boeri, R.; Salmaggi, A.; Tanzi, E., 1994: Eugenio Tanzi (1856-1934) and the beginnings of European neurology. Journal of the History of the Neurosciences 3(3): 177-185

Rosenblatt, M.B., 1949: The early diagnosis of carcinoma of the lung. New York Medicine 5(21): 16-20

Ojanen, M.; Orell, M.; Vaisanen, RA., 1978: Egg and clutch size in four passerine species in northern Finland. Egg and clutch size variations were studied in 4 passerines (breeding in nest-boxes) around Oulu (65.degree. N, 25.degree.30'E) in northern Finland: Parus major, Phoenicurus phoenicurus, Ficedula hypoleuca and Sturnus vulgaris. About 10,200 e...

Molinari, L.; Manrique, V., 1959: Comparative study of concentrations in the blood of para-aminosalicylic acid in tuberculous patients. Diseases of the Chest 36(1): 41-42

Vadrot, D., 1998: Organizations and networks. The English, the Americans...and us?. Journal de Radiologie 79(2): 113-114