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Distinct inhibition by non-peptide and peptide arginine vasopressin antagonists of vasopressin-induced activation of mitogen-activated protein kinase in cultured rat vascular smooth muscle cells


, : Distinct inhibition by non-peptide and peptide arginine vasopressin antagonists of vasopressin-induced activation of mitogen-activated protein kinase in cultured rat vascular smooth muscle cells. Biochemical and Biophysical Research Communications 200(2): 1155-1160

The preincubation of vascular smooth muscle cells VSMC) with a non-peptide arginine vasopressin (AVP) antagonist (OPC-21268) (0.5 mM) for 10 min completely inhibited the 1 mu-M AVP-induced activation of mitogen-activated protein (MAP) kinase but did not affect the angiotensin II-, protein kinase C activator- or ionomycin-stimulated MAP kinase. Similar results were obtained with the simultaneous administration of AVP and OPC-21268. This inhibitory effect of OPC-21268 completely disappeared after washing the cells pretreated with OPC-21268. In contrast, the preincubation of VSMC with a peptide AVP antagonist, d(CH-2)-5Tyr(Me)AVP (1 mu-M), for 10 min completely blocked the 1 mu-M AVP-activated MAP kinase but the simultaneous administration of d(CH-2)-5Tyr(Me)AVP With AVP could inhibit that only by 40%. However, the washing procedure did not affect the inhibitory effect of d(CH-2)-5Tyr(Me)AVP. These results indicate that OPC-21268 is a specific AVP antagonist to inhibit the AVP-induced activation of MAP kinase. The antagonistic effect of OPC-21268 is also suggested to be relatively weak but prompt as compared to that of a peptide AVP antagonist d(CH-2)-5Tyr(Me)AVP.

US$19.90

PMID: 8179597

DOI: 10.1006/bbrc.1994.1572


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