+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Distinct inhibition by non-peptide and peptide arginine vasopressin antagonists of vasopressin-induced activation of mitogen-activated protein kinase in cultured rat vascular smooth muscle cells

, : Distinct inhibition by non-peptide and peptide arginine vasopressin antagonists of vasopressin-induced activation of mitogen-activated protein kinase in cultured rat vascular smooth muscle cells. Biochemical and Biophysical Research Communications 200(2): 1155-1160

The preincubation of vascular smooth muscle cells VSMC) with a non-peptide arginine vasopressin (AVP) antagonist (OPC-21268) (0.5 mM) for 10 min completely inhibited the 1 mu-M AVP-induced activation of mitogen-activated protein (MAP) kinase but did not affect the angiotensin II-, protein kinase C activator- or ionomycin-stimulated MAP kinase. Similar results were obtained with the simultaneous administration of AVP and OPC-21268. This inhibitory effect of OPC-21268 completely disappeared after washing the cells pretreated with OPC-21268. In contrast, the preincubation of VSMC with a peptide AVP antagonist, d(CH-2)-5Tyr(Me)AVP (1 mu-M), for 10 min completely blocked the 1 mu-M AVP-activated MAP kinase but the simultaneous administration of d(CH-2)-5Tyr(Me)AVP With AVP could inhibit that only by 40%. However, the washing procedure did not affect the inhibitory effect of d(CH-2)-5Tyr(Me)AVP. These results indicate that OPC-21268 is a specific AVP antagonist to inhibit the AVP-induced activation of MAP kinase. The antagonistic effect of OPC-21268 is also suggested to be relatively weak but prompt as compared to that of a peptide AVP antagonist d(CH-2)-5Tyr(Me)AVP.


PMID: 8179597

DOI: 10.1006/bbrc.1994.1572

Other references

Leonard, H.; Forsyth, R., 2001: Friedreich's ataxia presenting after cardiac transplantation. A 4 year old boy underwent cardiac transplantation because of cardiomyopathy with ischaemia. Following transplantation he developed neurological signs of Friedreich's ataxia and the diagnosis was confirmed with genetic testing. Cardiomyopathy...

Carlyle, P.F.; Cohn, J.N., 1990: Systemic and regional hemodynamic effects of alpha-adrenoceptor blockade in chronic left ventricular dysfunction in the conscious dog. In seven dogs with long-standing left ventricular dysfunction induced 16 weeks earlier by repetitive transmyocardial direct current (DC) shock, the acute hemodynamic effect of the alpha 1-adrenoceptor antagonist urapidil was studied. Left ventricu...

Warburton D.; Bui K.C.; W.F.; Buckley S.; Williams R.; Carbonaro Hall D.; Hall F., 1992: Developmental and cell cycle regulation of cyclin d expression in alveolar epithelial cells. Pediatric Research 31(4 PART 2): 365A

Dahaba, A.A., 2005: Different conditions that could result in the bispectral index indicating an incorrect hypnotic state. Since its introduction in 1996, the Bispectral Index (BIS) has gained increasing popularity in daily anesthesia practice. However, numerous reports have been appearing in the literature of paradoxical BIS changes and inaccurate readings. The purpo...

Posfai, E.; Petropoulos, S.; de Barros, F.Regina.Oliveira.; Schell, J.Paul.; Jurisica, I.; Sandberg, R.; Lanner, F.; Rossant, J., 2017: Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. The segregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determined by position-dependent Hippo signaling. However, the window of responsiveness to Hippo signaling, the exact timing of lineage commitment...

Anonymous, 1978: The four newly-risen industrial cities along the Ch'ang Chiang in An-hui. China Pictorial 3 (357)): 30-33

Barger, L.K.; Lockley, S.W.; Rajaratnam, S.M.W.; Landrigan, C.P., 2009: Neurobehavioral, health, and safety consequences associated with shift work in safety-sensitive professions. Almost 15% of the full-time workers in the United States are shift workers. We review the physiologic challenges inherent not only in traditional night or rotating shifts but also in extended-duration shifts and other nonstandard hours. The challe...

Adachi H.; Nakamura H.; Ohnishi H.; Ishihara T.; Uchino F.; Fujinaka S.; Isobe J., 1978: The fine structure of the spleen and liver in a patient with hereditary stomatocytosis. Japanese Journal of Clinical Electron Microscopy 11(5-6): 707-708

Muñoz Torres, M.; Jodar Gimeno, E.; Reyes Garcia, R.; Martínez Diaz Guerra, G.; Amado, J.A.; Gaztambide, S.; Quesada Gómez, J.M.; Carazo, A.Moreno.; Albarrán, A.Jara.; Carrasco, A.Jesús.Blanco.; Guzmán, A.López.-Guzman.; Gil, A.Lisbona.; Villaplana, C.Rafael.Argente.; Sanchez Juan, C.; Sola Lopez, D.; Guerrero, D.Bellido.; Esteve, E.; Grande, E.Jose.Losada.; Ruiz Perez, E.; Jódar Gimeno, E.; Pérez, J.Acha.; Javier del Cañizo Gomez, F.; Maravall Royo, F.Javier.; Sellés, F.Piñon.; Diaz, 2013: Results from a national survey on the management of primary hyperparathyroidism. Management of primary hyperparathyroidism (PHPT) continues to be challenging. At the Third International Workshop on PHPT, recent data on this disease were reviewed and new clinical recommendations were developed. There are few data on the influen...

Asok Saha, 1998: Effect of cultivars and row directions on light transmission by dry (Boro) season rice. A field experiment was conducted to study the effect of cultivars and row directions on light transmission by the rice crop during the dry season on a lowland alluvial soil (entisol). All the 5 cultivars transmitted a lower percentage of light thr...