+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Do naturally occurring autoantibodies participate in the constitution of the pathological B-cell repertoire in systemic lupus erythematosus?

, : Do naturally occurring autoantibodies participate in the constitution of the pathological B-cell repertoire in systemic lupus erythematosus?. Journal of Autoimmunity 9(2): 247-257

Systemic lupus erythematosus (SLE) is the prototype of systemic autoimmune diseases. In both human and mouse SLE diseases, the autoimmune response targets a restricted set of autoantigens. Many of them are nucleic acids and proteins involved in the synthesis and processing of DNA or RNA, a characteristic which should be taken into consideration to elucidate the origins of non organ-specific autoantibodies. Several observations, in particular those obtained from experimental models of SLE induced in normal mice, suggest that the breakdown of B-cell tolerance occurs in the periphery. Herewith, we present data further supporting the proposition that SLE-associated autoantibodies originate from natural autoantibody-secreting B cells activated in the internal environment of lupus mice. Thus, one may hypothesize that certain clones of the expanded primary B-cell repertoire are selected to differentiate into harmful IgG autoantibody-secreting clones, thereby raising the question of the nature of immunogenic structures involved in SLE. Our analysis of the immunochemical and structural properties of anti-nucleosome and anti-myeloperoxidase monoclonal antibodies derived from (NZB times NZW)F1 mice leads us to propose that complexes formed by the association of DNA and DNA-binding proteins and, more generally, by anionic molecules associated with proteins, possess a selective advantage over other autoantigens to induce the differentiation of certain B-cell clones and the very special profile of the SLE-autoimmune response. These DNA/DNA-protein complexes could also play a role in the activation of the T-cell compartment in SLE.


PMID: 8738970

DOI: 10.1006/jaut.1996.0031

Other references

Barberis, C., 1982: Half time agriculture in Italian agricultural policy and statistics. In: Part time farming -- the conference on the Ile d'Abeau (France) November 1981. Several sections deal with different general and legal aspects of part time farming: its definition, its statistical measurement; the farmer, his family and his earnings; earnings of full time and part time farmers in the period 1978-80.

Morahan P.S.; Barnes D.W.; Munson A.E., 1978: Relationship of molecular weight to anti viral and anti tumor activities and toxic effects of maleic anhydride di vinyl ether poly anions. Cancer Treatment Reports 62(11): 1797-1805

Hamid T.A.-Saad; Sabah M.S.amshoom; Jamal K.A.aychi, 1998: Seasonal distribution of dissolved and particulate hydrocarbons in Shatt Al-Arab Estuary and the north-west Arabian Gulf. Marine Pollution Bulletin 36(10): 850-855

Raikova, A.P.; Klimenko, S.M.; Kostyrko, I.N.; Gromashevskii, V.L.; L'vov, D.K., 1971: The ability of Sumah virus of the Ukuniemi group to reproduce in Aedes aegypti mosquitoes. Voprosy Virusologii 16(6): 731-735

Wang Haoran; Zhu Guorong; Wang Xiaoqin, 2001: Study on exploitation of groundwater at headstream area of Xiaofu River. Groundwater control and recharge to the downstream in Nanshentou-Yaoguang area is studied systematically by using numerical simulation and optimal control modeling. Nanshentou-Yaoguang area is located at the headstream valley of Xiaofu River in Zi...

Walker, J.C.; Patel, P.N., 1964: Splash dispersal and wind as factors in epidemiology of halo blight of bean fPhaseolus vulgaris. During 55-60-day period from planting to time of harvest for processing of snap beans in Wisconsin, diseased plants appeared up to 85 ft from the source of inoculum, provided by planting infected seed. Under these conditions, as few as 12 infected...

González-González, Jé.Alberto.; García-Compean, D.; Vázquez-Elizondo, G.; Garza-Galindo, A.; Jáquez-Quintana, J.Omar.; Maldonado-Garza, Héctor., 2011: Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. Clinical and endoscopic features of cirrhotic patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) have been rarely reported and clinical outcomes and predictors of mortality have not been evaluated. 1) To describe the clinical featu...

Niccolai L.; Luperini G.; Rosellini G., 1982: Cardiac involvement in the course of infectious mononucleosis. The clinical, ECG, anatomopathological and statistical aspects of heart involvement in infectious mononucleosis are discussed. Comparison of a personal series with those of other workers reveals the frequency of isolated ECG abnormalities devoid o...

Westerman M., 1983: Chiasma frequency and variability of morphological characters in populations of 2 grasshopper species. Between Individual Variation (BIV) for 4 morphological characters was scored in a number of populations of the grasshoppers Phaulacridium marginale and P. otagoense collected during the 1973 meiotic season from South Island, New Zealand. In all bu...

Bagirov, V.; Sheichenko, V.; Gasanova, R.; Pimenov, M., 1978: Study of lactones from Ferula malacophyla. Khimiia prirodnykh soedinenii: ) 445-449