+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis

, : Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis. Vision Research. 38(11): 1723-1729, E

The paper reviews evidence that before any change in diabetics' fundi, changes occur to blood flow, ERG and visual functions. In the case of colour vision and contrast sensitivity, the changes are partially reversed by breathing oxygen, and therefore are the result of retinal hypoxia. There are also other evidences that hypoxia is a major factor in the development of diabetic retinopathy (DR). Therefore in diabetics with early retinopathy, but normal photopic vision, functional disturbance might appear in dark adaptation, since in such circumstances, (as shown by Linsenmeier and his colleagues) the already low retinal PO2 markedly decreases. This hypothesis has been tested and results consistent with the hypothesis (and with a number of older reports) have been obtained. The significance of this finding to early DR is discussed, and a mechanism suggested whereby prolonged periods of hypoxia during dark adaptation could generate changes in retinal capillaries. Such periods occur each night, and their elimination in diabetics could be therapeutic.


PMID: 9747505

DOI: 10.1016/s0042-6989(98)00004-2

Other references

Faruqi, S.A., 1979: Libyan grasses 4. size of pollen and stomata in determining ploidy level in hyparrhenia hirta. Size of pollen and stomata in the Libyan populations of H. hirta with 2n = 36, 54 and 56 chromosomes were compared. Significant difference was found only in the pollen size of 2n = 36 chromosome plant when compared to 2n = 54 and 56 chromosome pla...

Gzhegotskii M.I.; Kuz'minov B.P.; Sharova T.I.; Kokot V.R.; Zhuk S.Sh; Vus M.M., 1987: Justification of the maximum allowable concentration of o methyl o ethylchlorothiophosphate in the air of a work area. Gigiena Truda i Professional'nye Zabolevaniya (6): 57-58

Leung, H.Y.; Cooper, S.; Razack, A.H.; Falzon, M.; Abel, P.D., 1996: Ureteric filling defect. Postgraduate Medical Journal 72(854): 759-760

Litoshko D.N.; Bukanov V.V., 1989: Lazulite from the Northern Urals. Zapiski Vsesoyuznogo Mineralogicheskogo Obshchestva 118(1): 35-41

Murchison, J.F.; Shields, M.B., 1990: Limbal-based vs fornix-based conjunctival flaps in combined extracapsular cataract surgery and glaucoma filtering procedure. Extracapsular cataract extractions and posterior chamber intraocular lens implantations combined with glaucoma filtering procedures were done in 47 eyes of 43 consecutive patients who had coexisting cataract and glaucoma. A limbal-based conjunctiv...

Ishikawa, A.; Yoshihara, T.; Nakamura, K., 1994: Structure-activity relationships of jasmonates in the induction of expression of two proteinase inhibitor genes of potato. Expression of genes coding for wound-inducible cathepsin D inhibitor (CDI) and proteinase inhibitor II (PI-II) of potato were induced in leaves upon treatment with methyl jasmonate (MJA) with similar time and concentration dependences. The respons...

Chan, M-Fen.; Dowsett, M.; Folkerd, E.; Wareham, N.; Luben, R.; Welch, A.; Bingham, S.; Khaw, K-Tee., 2007: Past oral contraceptive and hormone therapy use and endogenous hormone concentrations in postmenopausal women. Exogenous sex hormone use is associated with many health effects. Current exogenous hormone use influences endogenous sex hormone levels, but little is known about longer term effects on endogenous hormones after cessation of use. The aim of this...

Depostis, P.; Touzeau, D., 1992: Suburbs in difficulty: the relegation. Soins. Psychiatrie: 10-12

Willenegger, H., 1953: Problems of operative therapy of fractures. Langenbecks Archiv für Klinische Chirurgie ... Vereinigt Mit Deutsche Zeitschrift für Chirurgie 276: 173-180

Lipton, H.A.; Jupiter, J.B., 1987: Streptokinase salvage of a free-tissue transfer: case report and review of the literature. Postoperative thrombosis is a devastating complication after a microvascular free-tissue transfer. We are reporting the case of a clinical free osteomyocutaneous flap (fibula, peroneal, and soleus muscle, and skin) which suffered recalcitrant post...