+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dose-response relationship between coffee and the risk of pancreas cancer

, : Dose-response relationship between coffee and the risk of pancreas cancer. Japanese Journal of Clinical Oncology 26(1): 42-48

A case-control study was conducted and previous epidemiological data were reviewed in order to investigate the dose-response relationship between coffee and the risk of pancreas cancer. The case-control study was community-based and was carried out in Hokkaido, japan, employing 141 patients with pancreas cancer and 282 controls (two for each case) matched for sex, age and place of residence. The dose-response relationship between coffee (cups/day) and the relative risk of this disease formed a U-shaped curve. The lowest relative risks (0.18 for male and 0.53 for female) were found among "occasional" drinkers. Epidemiological articles published between 1981 and 1993 were selected from Index Medicus using the two key words "coffee" and "pancreas cancer". In many of the previous case-control studies the curve of the dose-response relationship was also U-shaped, when the relative risks were calculated specifically using four or five levels of coffee dose. The nadirs of the relative risks, most of which ranged from 0.5 to 0.7, were found most frequently at small doses (1-2 or 3-4 cups/day). The results of meta-analysis of these studies formed a U-shaped curve. Studies of other types showed almost the same results. Thus it appears that small amounts of coffee might prevent pancreas cancer, whereas large amounts might cause the disease.


PMID: 8551666

DOI: 10.1093/oxfordjournals.jjco.a023177

Other references

Souness, J.E.; Houghton, C.; Sardar, N.; Withnall, M.T., 1999: Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of Mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors. We investigated the suppressive effects of rolipram, RP 73401 (piclamilast), and other structurally diverse inhibitors of adenosine 3'5'-cyclic monophosphate (cAMP)-specific phosphodiesterase (PDE4) on anti-CD3-stimulated interleukin (IL...

Bas, A.; Gultekin, G.; Incir, S.; Bas, T.Ocek.; Emul, M.; Duran, A., 2016: Level of serum thioredoxin and correlation with neurocognitive functions in patients with schizophrenia using clozapine and other atypical antipsychotics. NlmCategory="UNASSIGNED">Thioredoxin is a serum antioxidant that has been investigated in the etiology of schizophrenia. The aim of this study is investigating the relationship between serum thioredoxin levels and cognitive functions...

Hallez, S.; Brulet, J-Marc.; Vandooren, C.; Maudoux, Fédéric.; Thomas, Séverine.; Heinderickx, M.; Bollen, A.; Wattiez, R.; Jacquet, A., 2004: Pre-clinical immunogenicity and anti-tumour efficacy of a deleted recombinant human papillomavirus type 16 E7 protein. Background: Current vaccination strategies against Human papillomavirus (HPV)-induced ano-genital cancers mostly target E7 from HPV16. However, the oncogenic nature of E7 raises potential human safety issues. Although the modifications abrogating...

Bondar Constantin, 1972: Computation of coarse sediment discharge on the Sulina Arm. Hidrotehnica 17(7): 370-375

Ascoli, M.; Segaloff, D.L., 1987: On the fates of receptor-bound ovine luteinizing hormone and human chorionic gonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization. Using a clonal strain of cultured Leydig tumor cells (designated MA-10), we have compared the fate of the receptor-bound ovine LH (oLH) and human CG (hCG) in cells incubated in the presence or absence of extracellular Na+. We have previously shown...

Sreenan, J.J.; Pettay, J.D.; Tbakhi, A.; Totos, G.; Sandhaus, L.M.; Miller, M.L.; Bolwell, B.; Tubbs, R.R., 1997: The use of amplified variable number of tandem repeats in the detection of chimerism following bone marrow transplantation A comparison with restriction fragment length polymorphism by Southern blotting. Chimerism analysis after allogeneic bone marrow transplantation (alloBMT) allows detection of early marrow engraftment, disease relapse, and graft rejection. Our objective was to do retrospective and prospective studies of chimerism analysis by re...

Barrett, A.M., 1969: A comparison of the effects of (plus of minus)-propranolol and (plus)-propranolol in anaesthetized dogs; beta-receptor blocking and haemodynamic action. Journal of Pharmacy and Pharmacology 21(4): 241-247

Paolucci, G.; Cagnasso, D.; Cassani, F.; Pattono, D., 2015: Council Regulation (EC) No. 1099/2009: State of the Art and Its Application in a Local Health Unit in Piedmont, Italy. NlmCategory="UNASSIGNED">In the last decade, the European Union has reinforced the concept of animal welfare throughout the food chain, from breeding to slaughtering. Studies and assessments of economic nature led to the adoption of R...

Landais, E.; Huang, X.; Havenar-Daughton, C.; Murrell, B.; Price, M.A.; Wickramasinghe, L.; Ramos, A.; Bian, C.B.; Simek, M.; Allen, S.; Karita, E.; Kilembe, W.; Lakhi, S.; Inambao, M.; Kamali, A.; Sanders, E.J.; Anzala, O.; Edward, V.; Bekker, L-Gail.; Tang, J.; Gilmour, J.; Kosakovsky-Pond, S.L.; Phung, P.; Wrin, T.; Crotty, S.; Godzik, A.; Poignard, P., 2016: Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort. Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has proven unsuccessful to date. Understanding the correlates and immunological...

Channing, A.; Maclean, GL., 1976: Analysis of vocalizations of the sociable weaver. Ostrich, 474: 223-225