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Effect of BCH 325 (Pro-D-Phe-Pro-Gly) on Central Dopaminergic Functions


, : Effect of BCH 325 (Pro-D-Phe-Pro-Gly) on Central Dopaminergic Functions. Peptides (Tarrytown) 16(4): 635-640

Three behavioral models were used to characterize the pharmacological action of BCH 325 on central dopaminergic transmission. The effect of acute SC treatment with BCH 325 upon dopaminergic mechanisms affecting motor activity was studied on the climbing behavior of mice. It was shown that the beta-casomorphin analogue evoked a dose-dependent increase in apomorphine (APO)-induced hypoactivity that was reversed by sulpiride (SULP). In in vitro studies on slices of nucleus accumbens of mice it could be demonstrated that 10-6 M APO caused a reduction of K+-stimulated (14C)dopamine (DA) release that was potentiated following simultaneous incubation with 10-6 M BCH 325. To prove a postsynaptic influence in D-1 receptor-mediated behavior pattern, the action of BCH 325 was studied on bromocriptine (BROMO)-evoked yawning behavior of rats after pretreatment with reserpine (RES) or saline. The peptide could not influence the BROMO yawning after saline administration, but it was able to normalize the number of yawns, which were reduced after RES. To investigate the effect of BCH 325 on postsynaptic D-2 receptors, jerking behavior on RES-pretreated rats after a high dose of BROMO was used. Following RES pretreatment only, the number of BROMO-induced jerks was decreased by treatment of rats with 0.5 mu-mol/kg BCH 325. In contrast, the jerking behavior was enhanced by 0.5 mu-mol/kg BCH 325 in rats that were additionally treated with alpha-methyl-p-tyrosine (MPT). In biochemical studies on slices of the nucleus accumbens of mice, the in vivo pretreatment with RES caused a reduction of K+-stimulated (14C)DA release that was blocked by the SC administration of 0.5 mu-mol/kg BCH 325. The results indicate that BCH 325 was not able to influence the action of DA agonists on postsynaptic localized D-1 receptors. BCH 325 potentiated the pharmacological action of dopaminergic agonists on presynaptic DA autoreceptors and on D-2 receptors on the postsynaptic site of dopaminergic transmission by an alteration of the efficacy of D-2 receptor-coupled processes. The tetrapeptide normalizes the reduced K+-stimulated DA release after RES pretreatment.

US$19.90

PMID: 7479296

DOI: 10.1016/0196-9781(95)00015-c


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Rancillac, A.; Rossier, J.; Guille, M.; Tong, X-Kang.; Geoffroy, Hélène.; Amatore, C.; Arbault, Séphane.; Hamel, E.; Cauli, B., 2006: Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. The tight coupling between increased neuronal activity and local cerebral blood flow, known as functional hyperemia, is essential for normal brain function. However, its cellular and molecular mechanisms remain poorly understood. In the cerebellum...

Dmitriev, Vs, 1980: Development in interfarm cooperation and agroindustrial integration in melioration. Vestnik sel'skokhoziaistvennoi nauki: (2) 16-22

Anonymous, 1969: Epidemiological studies in coronary heart disease. Canadian Medical Association Journal 100(15): 729-730

Fajbisowicz, S.; Lalanne, C.M.; Sarrazin, D.; Juillard, G., 1966: Telecobalt therapy of cancer of the rectum at the Institut Gustave-Roussy. Annales de Radiologie 9(11): 833-836

Kuwayama, S.; Nishijima, Y., 1951: On the local difference between two types of the puparia of the rice leaf-miner, Agromyza oryzae Munakata, with special reference to the morphological characters and seasonal prevalence. The puparia of A. oryzae are of 2 types, hibernating and non-hibernating, distinguishable by morphological and ecological characters. The authors discuss the problem of whether or not the local difference is found between 2 types. About 6600 pupar...

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Pasquarelli, G., 1966: The general medical and associated problems of the Italian migrant family. Medical Journal of Australia 1(2): 65-70

Valladares, A.A.; Díaz-Celaya, J.A.; Galván-Colín, J.; Mejía-Mendoza, L.M.; Reyes-Retana, Jé.A.; Valladares, R.M.; Valladares, A.; Alvarez-Ramirez, F.; Qu, D.; Shen, J., 2011: New Approaches to the Computer Simulation of Amorphous Alloys: A Review. In this work we review our new methods to computer generate amorphous atomic topologies of several binary alloys: SiH, SiN, CN; binary systems based on group IV elements like SiC; the GeSe<sub>2</sub> chalcogenide; aluminum-based syste...

Talmage James Edward, 1901: The Great Salt Lake. Scottish Geographical Magazine Pages 617-644