+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of S-adenosyl-L-methionine on brain muscarinic receptors of aged rats

, : Effect of S-adenosyl-L-methionine on brain muscarinic receptors of aged rats. European Journal Of Pharmacology Molecular Pharmacology Section. 9(3): 293-299

The number of muscarinic receptors in the striatum and hippocampus of aged rats is significantly lower than the number measured in young animals. The treatment of aged rats for 30 days with S-adenosyl-L-methionine (SAM) restored the number of muscarinic receptors to levels found in the striatum and hippocampus from young animals. We did not observe a clear-cut difference between the dissociation constants of untreated young and untreated or SAM-treated aged rats, whereas the binding capacity varied. Moreover, in vitro addition of SAM to hippocampal membranes from aged rats resulted in a significant increase in the number of binding sites. This in vitro effect was antagonized by S-adenosyl-L-homocysteine, a specific in vitro inhibitor of methyltransferase activity. The reduction in the muscarinic receptor density could be related to a decrease in neuronal membrance fluidity induced by aging, while its increase after SAM treatment might be ascribed to the ability of this methyl donor to increase the fluidity of cell membranes by stimulating phospholipid synthesis.


PMID: 1473553

DOI: 10.1016/0922-4106(92)90007-i

Other references

Gaudin, T.J.; Biewener, A.A., 1992: The functional morphology of xenarthrous vertebrae in the armadillo Dasypus novemcinctus (Mammalia, Xenarthra). In order to assess the mechanical properties of xenarthrous vertebrae, and to evaluate the role of xenarthrae as fossorial adaptations, in vitro bending tests were performed on posterior thoracic and lumbar vertebral segments excised from specimen...

Anonymous, 1988: TFS grid hazard. Protection report R8 PR: 88 (9)

Moore, S.R., 2008: The Citizen Soldier Support Program: building bridges between communities and military families. North Carolina Medical Journal 69(1): 56-58

Forsaith, A.L.; Horwitz, N.H.; Lofstrom, J.E., 1966: The resolution of a spark imaging camera with parallel channel collima-tors. The results of resolution measurements performed on a spark imaging camera are presented. The minimum separation distance is shown to be essentially defined by the collimator design. Excellent images of a hexagonally-shaped phantom are obtained wi...

Khalin, A.V.; Gornostaeva, R.M., 2008: On the taxonomic composition of mosquitoes (Diptera: Culicidae) of the world and Russian fauna (critical review). Critical analysis of the taxonomy problems in the mosquito family Culicidae has been carried out. Different conceptions on the family classification are considered in historical aspect. Debatable points of the systematics of tribe Aedini are expou...

Neistadt, M.I., 1945: The work of the Central Peat Experimental Station of the Commissariat of Agriculture during the War.. Part of the article discusses the importance of peat lands on account of the sphagnum moss growing on them. Composts of peat combined with lupins, dung, ash, phosphatite, or other materials-often obtainable locally-have been successfully used in p...

Grelsamer, R., P.; Proctor, C., S.; Bazos, A., N., 1994: Evaluation of patellar shape in the sagittal plane: A clinical analysis. A prospective study of 564 patients was performed to assess the correlation between patellar shape as seen on a lateral radiograph and 1) patellar pain and 2) the radiologic determination of patellar height. A classification of patellar shape was...

Szalkai S.; Havelda T.; Kardics I., 1999: Deep exploitation; Part II, Coal seams in Markushegy Mine. Banyaszati es Kohaszati Lapok, Banyaszat = Vengerskiy Zhurnal Gornogo Dela i Metallurgii, Gornoye Delo = Hungarian Journal of Mining and Metallurgy 132(4): 250-260

Tsai, C.C.; Collins, S.H.; Swanger, S.J., 1996: Ovarian Sertoli-Leydig cell tumor in an amenorrheic hirsute patient. As ovarian Sertoli-Leydig cell tumors are extremely rare, it appears worthwhile to report cases with uncommon clinical and/or laboratory findings. A 37-year-old nulligravida female was referred because of secondary amenorrhea and hirsutism for 11...

Agarwal, N.; Saha, S.; Srivastava, A.; Chumber, S.; Dhar, A.; Garg, S., 2008: Peritonitis: 10 years' experience in a single surgical unit. Peritonitis secondary to gut perforation is still one of the commonest surgical emergencies in India and is associated with high morbidity and mortality. The present study examines the aetiology and outcome of peritonitis cases operated on in our...