+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of preservatives on systemic delivery of insulin by ocular instillation in rabbits

, : Effect of preservatives on systemic delivery of insulin by ocular instillation in rabbits. Journal of Pharmacy and Pharmacology 46(11): 871-875

The effects of absorption promoters and ophthalmic preservatives on the systemic absorption of insulin through the ocular route were investigated in albino rabbits. Insulin absorption was evaluated by its hypoglycaemic response. Although ocular instillation of insulin alone did not decrease the serum glucose concentration, instillation of insulin with absorption promoters such as EDTA and saponin decreased it. The promoting effect depended on the concentration of the absorption promoters. Of ophthalmic preservatives investigated (benzalkonium chloride, paraben, 2-phenylethanol, benzyl alcohol and sorbic acid), benzalkonium, chloride and paraben showed promoting effects. The promoting effect for benzalkonium chloride was reversible and dependent on concentration of both benzalkonium chloride and insulin in the formulation.


PMID: 7897590

DOI: 10.1111/j.2042-7158.1994.tb05705.x

Other references

Schultz, U.; Idelberger, R.; Rossaint, R.; Buhre, W., 2002: Central anticholinergic syndrome in a child undergoing circumcision. We describe one of the few pediatric cases of central anticholinergic syndrome (CAS) in an 8-year-old boy undergoing elective surgery. Deep sedation, inadequate response to stimuli and reduced muscular tone of the upper airway resulting in airway...

Gileadt, O.; Sabban, A., 2003: Squid Sperm to Clam Eggs: Imaging Wet Samples in a Scanning Electron Microscope. Part of a special section of papers from the 2003 General Scientific Meetings of the Marine Biological Laboratory held at Woods Hole, Massachusetts, on August 11-13. A new technology for imaging wet biological samples is described. In wet scanning...

Farwell, J.R.; Dohrmann, G.J.; Flannery, J.T., 1984: Medulloblastoma in childhood: an epidemiological study. The authors have reviewed 143 cases of medulloblastoma in children aged 19 years or younger who were treated in a 42-year period and reported in the Connecticut Tumor Registry. About 20 cases have occurred in each 5-year period since 1950, but 31...

Braun, A.R.; Skene, L.; Merry, A.F., 2010: Informed consent for anaesthesia in Australia and New Zealand. The legal and ethical requirements related to an anaesthetist's communication with patients in preparing them for anaesthesia, assisting them in making appropriate decisions and obtaining consent in a formal sense are complex. Doing these thi...

Slovut D.; Wirtschafter J.; Stordal L.; Valentino J.; Mcloon L., 1991: Photochemomyectomy results in temporary but severe muscle injury in the rabbit orbicularis oculi muscle. Investigative Ophthalmology & Visual Science 32(4): 1242

Espadaler, X.; Garcia Berthou, E., 1997: Tapinoma pygmaeum , not a rare species. Tapinoma pygmaeum is an ant known from seven localities. Five of them are in the province of Girona (Spain). The apparent rarity and skewed distribution of this species is probably an artifact due to the confusion, in field samplings, with a simil...

Heller, G., 2011: Proportional hazards regression with interval censored data using an inverse probability weight. The prevalence of interval censored data is increasing in medical studies due to the growing use of biomarkers to define a disease progression endpoint. Interval censoring results from periodic monitoring of the progression status. For example, di...

Fattig, P.W., 1933: Food of the robber fly, Mallophora orcina (Wied.) (Diptera). Canadian Entomologist, 65: 119-120

Connally, G.E., 1972: The Occupational Safety and Health Act of 1970. Its impact on hospital supervisors. Supervisor Nurse 3(2): 56-61

Suppiah, S.; Chang, W.Liong.; Hassan, H.Abu.; Kaewput, C.; Asri, A.Anggeriana.Andi.; Saad, F.Fikri.Ahmad.; Nordin, A.Jalil.; Vinjamuri, S., 2017: Systematic Review on the Accuracy of Positron Emission Tomography/Computed Tomography and Positron Emission Tomography/Magnetic Resonance Imaging in the Management of Ovarian Cancer: Is Functional Information Really Needed?. Ovarian cancer (OC) often presents at an advanced stage with frequent relapses despite optimal treatment; thus, accurate staging and restaging are required for improving treatment outcomes and prognostication. Conventionally, staging of OC is perf...