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Effect of recombinant human erythropoietin on blood rheology of rat

, : Effect of recombinant human erythropoietin on blood rheology of rat. Clinical Hemorheology 14(1): 53-62

Recombinant human erythropoietin (rhEPO; 180 or 1800 IU per kg) was daily administered to 6 weeks old rats for 1 to 2 weeks. (1) The increase of blood viscosity in rhEPO-administered rats in a saturation manner entirely depends on the hematocrit (the plasma viscosity and the plasma protein composition were not altered by rhEPO-administration). (2) No change in red cell deformability was observed upon rhEPO administration. (3) The velocity of rouleaux formation in autologous plasma decreased in rhEPO-administered rats. (4) A considerable polycythemia with reticulocytosis was induced in dose- and duration-dependent manners but in a saturation manner: cell volume increased and intracellular hemoglobin concentration inversely decreased. The density distribution of red cells shifted towards low specific gravity and became heterogenous. (5) No drastic alterations in contents of 2,3-diphosphoglycerate and ATP were detected. In conclusion, the increase of blood viscosity upon daily administration of rhEPO was hematocrit-dependent, regardless of the appearance of red cells with large volume and low internal viscosity.


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