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Effects of natural human interleukin-6 on thrombopoiesis and tumor progression in tumor-bearing mice


, : Effects of natural human interleukin-6 on thrombopoiesis and tumor progression in tumor-bearing mice. Cancer Letters. 79(1): 83-89

The growth of inoculated colon 26 adenocarcinoma (colon 26) in mice gradually increased the platelet count owing to murine IL-6 secreted from the tumor, while Lewis lung carcinoma (LLC) decreased the platelet count in the hosts, depending on the tumor growth. Natural human IL-6 injections (hIL-6), 280 mu-g/kg/day, stimulated the platelet production in both types of carcinoma-bearing mice. When the administration of mitomycin C or cisplatin decreased the platelet number as a side reaction with a concomitant of suppressing the growth of colon 26 and LLC, respectively, hIL-6 could also increase the platelet count without the augmentation of tumor growth. However, loss of carcass weight was observed in colon 26-bearing mice treated with hIL-6, suggesting the development of cachexia is associated with hIL-6 administration. Despite the possibility of inducing cachexia in some types of tumors, our results suggest that IL-6 could be a useful means of restoring the decreased platelet number in cancer patients after intensive chemotherapy.

US$19.90

PMID: 8187058

DOI: 10.1016/0304-3835(94)90067-1


Other references

Brennan S.; Savage R., 1990: Embryonic transcriptional activation of a xenopus cytoskeletal actin gene does not require a serum response element. The Serum Response Element (SRE) is a sequence motif which activates transcription of certain genes in response to factors that stimulate cell proliferation. This motif is found in the promoter of a Xenopus laevis cytoskeletal actin gene, which is...

Powers, K.; Laufer, J., 1982: Laws affecting Wisconsin families: domestic violence. Publication Cooperative Extension Programs University of Wisconsin Extension: 82 (B3145)

Lees G.M., 1940: The search for oil. World production, world resources, and the technique of exploration.

Helige C.; Smolle J.; Zellnig G.; Fink Puches R.; Kerl H.; Tritthart H.A., 1991: Antiinvasive activity of dequalinium on k1735 m2 melanoma cells in vitro. European Journal of Cancer 27(SUPPL 3): S33

Schlesinger M.J., 1974: Mutationally altered rate constants in the mechanism of alkaline phosphatase ec 3131. Biochemical Journal: 845-852

Mettetal, J.T.; Muzzey, D.; Pedraza, J.M.; Ozbudak, E.M.; van Oudenaarden, A., 2006: Predicting stochastic gene expression dynamics in single cells. Fluctuations in protein numbers (noise) due to inherent stochastic effects in single cells can have large effects on the dynamic behavior of gene regulatory networks. Although deterministic models can predict the average network behavior, they fai...

Deby, C.; Goutier, R.; Barac, G., 1971: Peroxidation of unsaturated fatty acid esters injected into rats following x-irradiation. Archives Internationales de Physiologie et de Biochimie 79(3): 626-628

Zimmer, T.; Rucktaeschel, F.; Stoelzel, U.; Liehr, R.M.rco; Schuppan, D.; Stallmach, A.; Zeitz, M.; Weber, E.; Riecken, E.O.to, 1998: Endoscopic sclerotherapy with fibrin glue as compared with polidocanol to prevent early esophageal variceal rebleeding. Background/Aims: Endoscopic sclerotherapy is of proven benefit for patients after esophageal variceal bleeding, but is associated with substantial local and systemic complications. Since fibrin glue is a promising agent for endoscopic sclerotherap...

Grillo M., 1988: A study on the lichen flora and vegetation of the nuova gussonea botanic garden mount etna sicily italy. 75 infrageneric taxa of lichens are reported from the Nuova Gussonea Botanic Garden, situated on the southern slopes of M. Etna (Sicily). The most significant aspects of lichen vegetation on rock and bark are briefly described.

Ruderman, A.I.; Vaĭnberg, M.Sh.; Narkevich, B.Ia.; Korf, N.N., 1970: Method of dosage at the layer level of semiweakening of the absorbed dose in short-distance roentgenotherapy. Meditsinskaia Radiologiia 15(7): 52-55