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Effects of substance P on cardiovascular regulation in the rabbit


, : Effects of substance P on cardiovascular regulation in the rabbit. Journal Of The Autonomic Nervous System. 51(2): 143-152

The effect of substance P on blood pressure and aortic reflex was investigated in rabbits. Microinjections of substance P and Sar-9, Met(O2)-11-SP (a selective NK-1-receptor agonist) into the floor of the fourth ventricle led to a dose-dependent increase of blood pressure and a sharp enhancement of the baroreflex. These effects were abolished by pretreatment with SR 140333 (a selective NK-1-receptor antagonist). Intraventricular injection of the antagonist alone significantly decreased the amplitude of the aortic reflex. After bivagotomy, the amplitude of the parasympathetic component of the baroreflex decreased dramatically and substance P injections were no longer effective. Our results demonstrate that substance P activation of NK-1 receptors plays a major role in the modulation of the parasympathetic component of the baroceptor reflex.

US$19.90

PMID: 7537770

DOI: 10.1016/0165-1838(94)00126-5


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