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Effects of vitamin B12-deficiency on testes tissue in rats

, : Effects of vitamin B12-deficiency on testes tissue in rats. Journal of Nutritional Science and Vitaminology 38(4): 305-316

The state of vitamin B-12-deficiency in rats was evaluated by determination of hepatic vitamin B-12-dependent enzyme activities after the animals had fed on a vitamin B-12-deficient soybean protein diet for 150 days. The effect of vitamin B-12-deficiency on testicular tissue was also studied by morphological observations. Growth of vitamin B-12-deficient rats was retarded and marked increase in urinary methylmalonic acid was observed. Vitamin B-12 contents in the organs were depressed distinctly by the deficiency, especially in testes, vitamin B-12 content decreased to 2.5 ng/g. Hepatic methionine synthase and methylmalonyl-CoA mutase activities showed striking depression to 5% of the control rats and extreme vitamin B-12-deficiency was confirmed. Testes weight also showed marked decrease together with their relative weight per 100 g body weight. Morphological observations of testes of vitamin B-12-deficient rats revealed atrophy of the seminiferous tubules and aplasia of sperms and spermatids. The above results proved that vitamin B-12-deficiency affected rat testes, and suggested that the rat could be the animal model for elucidation of the mechanism of B-12 action on testicular functions.


PMID: 1291637

DOI: 10.3177/jnsv.38.305

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