+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Evidence that an angiotensin-converting enzyme inhibitor has a different effect on glomerular injury according to the different phase of the disease at which the treatment is started

, : Evidence that an angiotensin-converting enzyme inhibitor has a different effect on glomerular injury according to the different phase of the disease at which the treatment is started. Journal of the American Society of Nephrology 5(4): 1139-1146

In rats with streptozotocin-induced diabetes, the effect of an angiotensin-converting enzyme (ACE) inhibitor on the evolution of glomerular injury according to the time at which the treatment is started with respect to the onset of the disease was studied. Three groups of animals were used, a control Group 1 and two groups of diabetic rats treated with insulin (Groups 2 and 3). The latter were monitored until urinary protein excretion reached 40 to 50 mg/24 h (on average, 23 wk after the induction of the diabetes). At this time, Group 2 continued to receive insulin alone, whereas Group 3 was also given the ACE inhibitor moexipril for 8 more wk. Untreated diabetic rats showed a moderate increase in systolic blood pressure that was normalized by moexipril administration. Urinary protein excretion progressively increased during the 8-wk follow-up in untreated diabetics that, at the end of the study, developed moderate glomerular sclerosis. Moexipril treatment lowered urinary protein excretion to a normal range and completely prevented glomerular injury. Three other groups of rats were similarly treated, except that moexipril treatment was started later on (when proteinuria reached 100 to 200 mg/24 h, on average, 32 wk after the induction of diabetes), and were monitored for another 8 wk. Untreated and treated diabetics had comparable blood glucose levels throughout. Systolic blood pressure, significantly increased in untreated diabetic rats, was effectively controlled by moexipril administration. Unlike in the early phase of the disease, moexipril was unable to prevent the progressive increase in urinary protein excretion as well as the glomerular sclerotic lesions that developed in untreated diabetics. These results indicates that, in a model of streptozotocin-induced diabetes, ACE inhibition affords remarkable protection against the development of diabetic nephropathy, but only when treatment is started early in the course of the disease.


PMID: 7849255

Other references

Karickhoff S.W., 1980: Sorption kinetics of hydrophobic pollutants in natural sediments. Baker, R A (Ed ) Contaminants And Sediments, Vol 2 Analysis, Chemistry, Biology Xviii+627p Ann Arbor Science Publishers, Inc : Ann Arbor, Mich , Usa Illus P193-206

Benos, S.; Karasiotos, G.; Kalatzi, N., 1979: Efficacy of ketotifen in bronchial asthma. Ketotifen was administered orally during a period of three months to 30 patients suffering from bronchial asthma. It proved to be a strong antiasthmatic agent and the results obtained were positive, i.e.: Excellent in 21 patients (70%), very good...

Romeo, F.; Falbo, L.; Costanzo, V., 2016: Replication, checkpoint suppression and structure of centromeric DNA. NlmCategory="UNASSIGNED">Human centromeres contain large amounts of repetitive DNA sequences known as α satellite DNA, which can be difficult to replicate and whose functional role is unclear. Recently, we have characterized protein...

Ichihara, Y.; Fukuda, K.; Suzuki, K., 2000: The effect of periderm formation in the cortex of Pinus thunbergii on early invasion by the pinewood nematode. The distribution of cortical resin canals and periderm formation in the cortex of Pinus thunbergii was studied in relation to early invasion of the pinewood nematode, Bursaphelenchus xylophilus. Nematode invasion was restricted in stem cuttings of...

Li, Y-Wei.; Zhou, L-Shan.; Li, X., 2017: Accuracy of Tactile Assessment of Fever in Children by Caregivers: A Systematic Review and Meta-analysis. Fever is the most common complaint in the pediatric and emergency departments. Caregivers prefer to detect fever in their children by tactile assessment. To summarize the evidence on the accuracy of caregivers' tactile assessment for detectin...

Tighe, D.F.; Cascarini, L.; Collyer, J., 2007: Jaw fracture as a result of dog bite in a 9-month-old infant. Emergency Medicine Journal 24(7): 519-519

Johnson, Rh, 1980: A pecan marketing overview & a promotional effort. Proceedings: California 1980 Pecan Growers Conference July 1-1980 Visalia California: 3

Reisberg, E.E.; Hildebrandt, U.; Riederer, M.; Hentschel, U., 2014: Distinct phyllosphere bacterial communities on Arabidopsis wax mutant leaves. The phyllosphere of plants is inhabited by diverse microorganisms, however, the factors shaping their community composition are not fully elucidated. The plant cuticle represents the initial contact surface between microorganisms and the plant. We...

Anonymous, 1963: Revolution in maize. A popular account is given of the breeding of multieared and dwarf hybrids by commercial companies in the USA.

de Jong S., 1991: The use of spectroscopy to monitor soils and soil crusts. International Geoscience and Remote Sensing Symposium 11: 1187-1189