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Excitatory effects of algesic compounds on neuronal processes in murine dorsal root ganglion cell culture


, : Excitatory effects of algesic compounds on neuronal processes in murine dorsal root ganglion cell culture. Brain Research. 751(2): 348-351

The effects of algesic compounds on the distal portion of the processes of cultured dorsal root ganglion cells (C-fiber) of mouse were studied by patch-clamp whole-cell recording at the cell soma (cell body). The processes of the cell were isolated from the cell body with a separator. Bradykinin (BK, 10 mu-M), prostaglandin E-2 (PGE-2, 20 mu-M), and capsaicin (CAP, 2 mu-M) were applied to the processes of a cell on the third day after seeding, each of which evoked action potentials in the cell body. No desensitization was seen by the repeated application of BK to the processes. No action potentials in the cell body were observed when BK (10 mu-M) was applied concomitantly with tetrodotoxin (6 mu-M). These results suggest that the stimuli of algesic compounds to the neuronal processes of the cultured dorsal root ganglion cells are useful for studying the neuronal mechanism involved in pain.

US$19.90

PMID: 9099827

DOI: 10.1016/s0006-8993(97)00077-2


Other references

Rice, M.E.; Nicholson, C., 1988: Behavior of extracellular K+ and pH in skate (Raja erinacea) cerebellum. Ion-selective microelectrodes were used to measure extracellular K+ concentrations ([K+]o) and extracellular pH (pHo) in skate cerebellum under resting and stimulated conditions. Consistent with earlier ion analysis of elasmobranch cerebrospinal f...

Lantz, M.; Richter, J.; Olsson, I., 1993: Adherence of neutrophils induces release of soluble tumor necrosis factor receptors forms. European Journal of Haematology 51(5): 325

Kohlhagen, J.; Kelly, J., 2004: Prevalence of vascular risk factors and vascular disease in predialysis chronic renal failure. Patients with end-stage renal disease have a high mortality, with the majority of deaths due to vascular disease. The prevalence of vascular risk factors and vascular disease in predialysis chronic renal failure (CRF) is poorly characterized. The...

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Braithwaite Karen; Wignall Paul B., 1994: Internal wave erosion; application of the Baird and Brett model to the Mid-Carboniferous of western Ireland. Abstracts with Programs - Geological Society of America 26(7): 248

Axelrod, J.D.; McNeill, H., 2003: Coupling planar cell polarity signaling to morphogenesis. Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a rece...

Falkner, F.R., 1939: The limits of non-irrigated agriculture in Africa.. An account of a more complete paper in Petermanns Geographische Mitteilungen, with commentary by H. Scaetta. Various modes of obtaining water; proportion of areas cultivated and not; humidity, climate, duration of rains; soil deterioration.

Janssen, L.L.; Gessaman, P.H., 1975: Businessmen's funding sources, use of credit and assessment of credit system adequacy in two regions of rural Nebraska. A sample of sixty-seven businessmen in selected municipalities of two Rural Nebraska regions were interviewed to determine funding sources for business operations, credit usage and perceptions of credit system adequacy. Most respondents from both...

Heyssel, R.M., 1977: External constraints necessary to control hospital bed surplus. Hospital Progress 58(4): 6, 12-6, 12

Lowy, A., 1994: Are deprivation indicators a proxy for morbidity?. Journal of Public Health Medicine 16(1): 113-114