+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Expression and phosphorylation of rat c-met/hepatocyte growth factor receptor during rat liver regeneration

, : Expression and phosphorylation of rat c-met/hepatocyte growth factor receptor during rat liver regeneration. Journal Of Hepatology. 23(2): 174-183

Hepatocyte growth factor receptor is identified as a heterodimeric tyrosine kinase encoded by the c-met gene. This study was designed to determine how the c-met/hepatocyte growth factor receptor participates in the intracellular events involved in rat liver regeneration induced by administration of carbon tetrachloride. Expression of the rat c-met mRNA increased, peaking 24 h after carbon tetrachloride administration almost in parallel with MET protein expression. Histochemical studies demonstrated that expression of the rat c-met was enhanced in cells surrounding the damaged areas, and also that the distribution of cells expressing MET was almost in accordance with that of cells expressing proliferating cells nuclear antigen. The MET protein underwent intense tyrosine phosphorylation peaking at 12 h after carbon tetrachloride administration, and prior to DNA synthesis. Phospholipase C-gamma and phosphatidylinositol 3-kinase, intracellular signal transducing molecules containing Src homology 2 domain, were associated with the MET protein following tyrosine phosphorylation in vivo. These observations suggest that expression and tyrosine phosphorylation of MET protein associated with signal transducing molecules may provide a mechanism whereby hepatocyte growth factor exerts its action on hepatocyte growth during rat liver regeneration induced by carbon tetrachloride administration.


PMID: 7499789

DOI: 10.1016/0168-8278(95)80332-7

Other references

Venkatasubramanian,, C., 1981: Gasohol: a commercial perspective. Applied and environmental microbiology69(369): 187-204

Tsukamoto, Y.; Mabuchi, K.; Futami, T.; Kubotera, D., 1992: Motion of the bipolar hip prosthesis components. Friction studied in cadavers. It has been postulated that most hip motion occurs at the inner bearing in bipolar hip prosthesis. However, radiography and cineradiography analyses have shown that the inner bearing is not always the primary articulation. We studied the frictiona...

Malick, A.P.; Yurochko, A.D.; Burger, C.J.; Askew, D.; Elgert, K.D., 1989: Tumor-induced variations in a high molecular weight inhibitory monokine. A soluble inhibitor of T cell proliferation was demonstrated in splenic and peritoneal macrophage (M phi) culture supernatants and was variably glycosylated during tumor development. This factor(s) inhibited mixed lymphocyte reaction- (MLR) and co...

Nakasone, H.Y., 1953: Methods of breaking the dormancy of Gladiolus corms in Hawaii with special reference to the effects of ethylene chlorohydrin. Work presented here was an attempt to determine the applicability of chemical treatments to break the dormancy of gladiolus corms under local conditions. Chemical methods were tested against the standard cold storage method in common usage. The et...

Buszko, J., 1990: Studies on the mining lepidoptera of poland x. mining lepidoptera of torun and surrounding areas. The present paper contains a review of species of mining Lepidoptera collected in the town of Torun and its surroundings within the period 1977-1988. In the course of field investigations 293 species have been recorded. Full data on their host pla...

Charley, M.R.; Tharp, M.; Locker, J.; Deng, J.S.; Goslen, J.B.; Mauro, T.; McCoy, P.; Abell, E.; Jegasothy, B., 1990: Establishment of a human cutaneous T-cell lymphoma in C.B-17 SCID mice. Investigation into the immunobiology of cutaneous T-cell lymphomas (CTCL) would be facilitated by the development of a suitable experimental system. The recent use of mice with severe combined immune deficiency (SCID) as a vehicle to study the hum...

Spina, S.; Farlow, M., R.; Unverzagt, F., W.; Kareken, D., A.; Murrell, J., R.; Fraser, G.; Epperson, F.; Crowther, R.A.thony; Spillantini, M., G.; Goedert, M.; Ghetti, B., 2008: The tauopathy associated with mutation+3 in intron 10 of Tau: characterization of the MSTD family. Multiple system tauopathy with presenile dementia (MSTD) is an inherited disease caused by a (g) to (a) transition at position 3 in intron 10 of Tau. It belongs to the spectrum of frontotemporal dementia and parkinsonism linked to chromosome 17 wi...

Saad, W.E.A., 2010: Internalization of a second transhepatic biliary access with a captured microwire forced-buckle maneuver: description, anatomic applications, and results. Percutaneous biliary drains are classified into external and internal/external drains. Internal/external drains can drain bile externally and internally (ie, anatomically) into bowel. Internal drainage is usually desired because it is associated w...

Schuyler, M., 2003: Link between anthrax immunization and hypersensitivity pneumonitis?. Chest 123(5): 1769; Author Reply 1769-70

Augustine, J., 2006: Fast thinking. How to improve the delivery of stroke care. Emergency Medical Services 35(5): 32-33