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Expression of E-cadherin and catenins in invasive mammary carcinomas


, : Expression of E-cadherin and catenins in invasive mammary carcinomas. Anticancer Research 17(1b): 561-567

E-Cadherin has been shown to be an invasion tumor suppressor gene, but few epidemiological studies have revealed relationships between loss of E-cadherin expression and invasive tumor growth and/or metastasis. The adhesive function of E-cadherin is dependent on the integrity of the catenin components which link E-cadherin to the actin filaments. In order to achieve a better correlation between the loss of cell adhesion and metastasis in cancer, we decided to investigate both E-cadherin and the catenins. 157 archival primary mammary carcinomas were immunohistochemically studied using antibodies against E-cadherin, alpha-, beta- and gamma-catenin. The following results were obtained: (a) Independent of the presence; of E-cadherin, loss of expression of one or multiple catenins was noted; (b) loss of E-cadherin and alpha-catenin expression was more pronounced in lobular-type than ductal-type carcinomas, c) axillary lymph node metastases were completely lacking only in the group where expression of E-cadherin, alpha- and beta- catenin was preserved: d) no correlation between expression of c-erbB-2 and E-cadherin or one of the catenins was found. The results demonstrate for the first time that consideration of both the expression of E-cadherin and of the three catenins is useful in evaluation of the metastatic potential of mammary carcinomas.

US$29.90

PMID: 9066580


Other references

Cheng, H.; Yibchok Anun, S.; Coy, D.H., 2002: SSTR2 mediates the somatostatin-induced increase in intracellular Ca2+ concentration and insulin secretion in the presence of arginine vasopressin in clonal b-cell HIT-T15. Life Sciences 71(8): 7-36

Andersen, N.D., 2015: Parting ways with routine postoperative chest radiographs: Are we ready to cut the cord?. Journal of Thoracic and Cardiovascular Surgery 150(1): 230-231

Bain Harry Foster, 1932: Memorial of Samuel Walker Beyer. Geological Society of America Bulletin 43(1): 44-46

Wilkins, H.; Heins, R., 1986: Log of Easter lily records and notes forcing year 1986-1987--Easter, April 19, 1987. Minnesota State florists bulletin 35(6): 13-17

Dominova, I.N.; Kublanov, I.V.; Podosokorskaya, O.A.; Derbikova, K.S.; Patrushev, M.V.; Toshchakov, S.V., 2013: Complete Genomic Sequence of "Thermofilum adornatus" Strain 1910bT, a Hyperthermophilic Anaerobic Organotrophic Crenarchaeon. The complete genomic sequence of a novel hyperthermophilic crenarchaeon, strain 1910b(T), was determined. The genome comprises a 1,750,259-bp circular chromosome containing single copies of 3 rRNA genes, 43 tRNA genes, and 1,896 protein-coding seq...

Anonymous, 1994: Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. The Liver Cancer Study Group of Japan. Great progress in the diagnosis and surgical treatment of hepatocellular carcinoma (HCC) has led to an increased number of resectable cases. Much attention has been paid to the factors affecting long term survival of patients with HCC after partia...

Short L.L., 1969: A new species of blackbird agelaius from peru agelaius xanthopthalmus new species cardinalis cardinalis agelaius cyanopus agelaius thilius. Occasional Papers Of The Museum Of Zoology Louisiana State University: 8

Worobiec Elzbieta; Worobiec Grzegorz, 2005: Leaves and pollen of bamboos from the Polish Neogene. Recently discovered fossil bamboo leaves and pollen are described from the Neogene of Poland. Morphological analysis of fossil leaves from the Late Miocene deposits of the Belchatow Lignite Mine, Central Poland have allowed them to be determined a...

Colas-Beloour, J.; Vervent, G., 1956: Transmission de divers spirochetes de la fievre recurrente par une souche soudanaise de l' Ornithodoros erraticus Lucas (= O. e. var. sonrai J. Sautet H. Marneffe et M. Wickowsky 1944). Bulletin de la Societe de Pathologie Exotique, 48(1955): 747-757

Schack, L.M.H.; Petersen, S.E.; Nielsen, S.; Lundby, L.; Høyer, M.; Bentzen, L.; Overgaard, J.; Andreassen, C.N.; Alsner, J., 2017: Validation of genetic predictors of late radiation-induced morbidity in prostate cancer patients. Normal tissue morbidity sets the dose limit for radiotherapy (RT) in cancer treatment and has importance for quality of life for cancer survivors. A previous study of prostate cancer patients treated with RT generated clinical data for radiation-i...