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Expression of Ly-6C on microglia in the developing and adult mouse brain

, : Expression of Ly-6C on microglia in the developing and adult mouse brain. Neuroscience Letters. 239(1): 17-20,. 12

Expression of Ly-6C, a murine homolog of human CD59, in the brain was examined immunologically using an ER-MP20 monoclonal antibody both in vitro and in vivo. Ly-6C was expressed both on the isolated microglia and on microglia in the developing and adult cerebellum. The number of cerebellar microglia expressing Ly-6C markedly increased during the first postnatal week in mouse development. The expression of Ly-6C on microglia in the developing and adult brain may be related to the unique role(s) of microglia under normal and/or pathological conditions of the brain.


DOI: 10.1016/s0304-3940(97)00878-1

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