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Extrinsic neural control of nitric oxide synthase expression in the myenteric plexus of rat jejunum


, : Extrinsic neural control of nitric oxide synthase expression in the myenteric plexus of rat jejunum. Journal Of Physiology (cambridge). 507(2): 549-560, Ch 1

1. The role of extrinsic innervation in the expression of nitric oxide synthase (NOS) in the myenteric plexus remains unknown. In this study, we investigated the effect of extrinsic denervation on NOS expression in rat jejunum. 2. NG-nitro-L-arginine methyl ester (L-NAME)-sensitive non-adrenergic, norcholinergic (NANC) relaxations induced by transmural nerve stimulation were significantly increased in muscle strips obtained from rats treated with splanchnic ganglionectomy or 6-hydroxydopamine (6-OH-dopamine). Truncal vagotomy or treatment of the coeliae ganglia with capsaicin did not significantly affect NANC relaxations. 3. The number of NOS-immunopositive cells in the myenteric plexus was significantly increased in tissues obtained from rats treated with splanchnic ganglionectomy or 6-OH-dopamine. 4. Western blot analysis and Northern blot analysis showed a significant increase in the density of the immunoreactive NOS band and the NOS mRNA band, respectively, of the tissues obtained from rats treated with splanchnic ganglionectomy or 6-OH-dopamine. 5. Truncal vagotomy or treatment of the coeliac ganglia with capsaicin did not significantly affect the density of NOS band or NOS mRNA band. 6. It is concluded that neuronal NOS expression in the myenteric plexus is independent of vagus nerve and is negatively regulated by the splanchnic nerves in the rat small intestine.

US$19.90

PMID: 9518712

DOI: 10.1111/j.1469-7793.1998.549bt.x


Other references

Smith, H.R.; Grindley, J.N.; Grindley, N.D.; Anderson, E.S., 1970: Derepression of F-lac in Salmonella typhimurium by a determinant for kanamycin resistance. Genetical Research 16(3): 349-353

Wu, J.S.; Saluja, S.; Garcia-Tsao, G.; Chong, A.; Henderson, K.J.; White, R.I., 2006: Liver involvement in hereditary hemorrhagic telangiectasia: CT and clinical findings do not correlate in symptomatic patients. The purpose of our study was to report the multiphasic CT findings in patients with symptomatic liver involvement by hereditary hemorrhagic telangiectasia (HHT) and to correlate the CT findings with the type of clinical presentation. Patients with...

Kozakov I.K.; Kovach V.P.; Bibikova Y.V.; Kirnozova T.I.; Zagornaya N.Y.; Plotkina Y.V.; Podkovyrov V.N., 2007: Age and sources of granitoids in the Caledonides-Hercynides junction zone in southwestern Mongolia; geodynamic implications. Petrologiya 15(2): 133-159

Kennedy, W.P., 1963: The genesis of a drug. Practitioner 190: 8-13

Graham, W.G.; Gaensler, E.A., 1965: Talco-silicosis in a rubber worker. This is a report of a rubber grinder with talco-silicosis who presented with unusual clinical features. The diagnosis was supported by chemical and physical analysis of dust at his place of work. The importance of an adequate occupational history...

Malachi, T.; Bichachu, S.; Halbrecht, I., 1982: Prostaglandins and cyclic-AMP in human semen. Normospermic, oligospermic and azoospermic semen samples were analysed for prostaglandins of the E groups and for cyclic AMP. The whole procedure was rapidly performed in a nitrogen atmosphere. Higher levels of total PGEs (PGEs+19-hydroxy PGEs) we...

Rossi, S.; Sevignani, C.; Nnadi, S.C.; Siracusa, L.D.; Calin, G.A., 2008: Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs, RNAs that do not code for proteins) that regulate the expression of target genes at the posttranscriptional or posttranslational level. Many miRNAs have conserved sequences between distantly rel...

Hull, O.H., 1955: Critical analysis of two hundred twenty-one thyroid glands; study of thyroid glands obtained at necropsy in Colorado. During 1952 and 1953, 221 thyroid glands from necropsies in the Colorado General Hospital were examined from settlers who had dwelt for some time in the Rocky Mountain area, a high, fresh-water, potentially goitrous. region. Normal thyroids weighe...

Mayaux, P.; Malingreau, J.P., 2000: The forest cover of Central Africa: a new inventory. This article discusses how new remote sensors and powerful computing tools help refine the thematic knowledge of ecosystems of the whole Congo Basin in Central Africa. These new techniques permit the frequent combination of data coming from variou...

Usategui Echevarría, R.; Oliver, C.; Laffite, J.M.; Jimeno Carruez, A.; Ortíz Manchado, O.; Vague, J., 1975: Plasma ACTH and beta-MSH in normal subjects and in pituitary-adrenal pathology and in non-endocrine pigmentation disorders. Revista Clinica Espanola 139(2): 163-169