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Fluid and protein secretion by the submandibular glands of weanling rats in response to various agonists

, : Fluid and protein secretion by the submandibular glands of weanling rats in response to various agonists. Archives Of Oral Biology. 39(11): 979-984

Secretion of fluid and protein by the submandibular glands of 25-day-old rats was investigated by stimulation with 22 sialogogues classified into five categories, four cholinergic, five beta-1-, seven alpha-1- and three alpha-2-adrenergic, and three peptidergic, at optimal doses. For fluid secretion, cholinergic and peptidergic agonists were the most powerful, whereas the beta-1- and alpha-1-adrenoceptor agonists were the most effective for the concentration of protein among the five categories, except for methoxamine. For total output of protein, the beta-1- and alpha-1-adrenoceptor agonists and pilocarpine were the most powerful among the 22 agonists, except for methoxamine and norephedrine. Cholinergic, peptidergic and alpha-2-adrenergic agonists among the five categories were less effective for protein secretion, except for pilocarpine. For the specific activity of esteroprotease, methoxamine and oxymetazoline, as alpha-adrenoceptor agonists, were the most powerful among the 22 agonists. Thus fluid and protein secretion evoked from the submandibular glands of weanling rats in response to a wide variety of agonists are similar to those of adult rats.


PMID: 7535048

DOI: 10.1016/0003-9969(94)90082-5

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