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Fluoroolefin containing dipeptide isosteres as inhibitors of dipeptidyl peptidase IV(CD26)


, : Fluoroolefin containing dipeptide isosteres as inhibitors of dipeptidyl peptidase IV(CD26). Tetrahedron 52(1): 291-304

(Z)-(S)Ala-PSI(CF dbd C)-(RS)-Pro containing N,O-diacylhydroxamic acid type protease inhibitors have been prepared for the study of the influence of prolylamide bond geometry on the inhibition of dipeptidyl peptidase IV(CD26). The synthesis is based upon the use of tert-butyl alpha-fluoro-alpha-trimethylsilylacetate in a variation of the Peterson olefination procedure to construct the necessary functionalized fluoroolefin.

US$19.90

DOI: 10.1016/0040-4020(95)00912-r


Other references

Anonymous, 2014: The 2013 IT Vendor Survey. Behavioral Healthcare 33(5): 29-31

Schiro Geist, C., 1980: Development of an independent living rehabilitation program curriculum. Journal of Rehabilitation 46(2): 53-55

Ahrens Thomas J.; Katz Samuel, 1962: Ultrasonic observation of the pressure-induced calcite-aragonite transition in two limestones. Transactions - American Geophysical Union 43(4): 456

Mccoy H.; Orrell R.; Kenney M.A.; Williams L., 1989: Effects of storage time on bones from rats fed low magnesium or low calcium diets. FASEB Journal 3(3): A771

Xu, J.; Tseng, Y.; Wirtz, D., 2000: Strain hardening of actin filament networks. Regulation by the dynamic cross-linking protein a-actinin. The Journal of Biological Chemistry 275(46): 886-92

Gschwendtner, L., 1933: Ein neuer Hyphydrus aus Zentralafrika. H. conradsi (p.90), Tanganyika.

Styczynski, T., 1984: Results of radio anatomic investigations of the lumbar spine in patients with disc herniation and healthy persons 2. spinal canal and inter vertebral foramina. Radioanatomic research on the spinal canal and intervertebral foramina was carried out in 225 patients suffering from disc herniation. The control group numbered 50. Statistically significant differences in spinal canal structure were observed, sh...

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