geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Functional activity of blood polymorphonuclear leukocytes as an oxidative stress biomarker in human subjects


, : Functional activity of blood polymorphonuclear leukocytes as an oxidative stress biomarker in human subjects. Free Radical Biology & Medicine. 24(9): 1411-1418, E

In the present work, we studied the role of polymorphonuclear leukocytes (PMN) in aged individuals and coronary heart disease (CHD)-bearing patients, two physiopathological processes associated with overproduction of reactive oxygen species (ROS). The effects of antioxidant supplementation on the functional activity of PMN from CHD patients were also determined. The function of PMNs was evaluated by measuring of phagocytosis, killing activity, and ROS production. Luminol amplified chemiluminescence (CL) was used to estimate ROS production by stimulated PMNs. Total cholesterol and the LDL-cholesterol fraction from CHD patients were found to be higher than those recommended, returning to normal levels after antioxidant therapy. PMN CL of CHD patients was found to be higher than the associated control groups. Antioxidant therapy administrated to CHD patients lead to an increase in the killing activity accompanied by a decrease in PMN CL of these subjects. The study also showed that killing activity of PMN from human subjects over 60 years was significantly lower than the activity measured in younger subjects. PMN CL produced after stimulation was found to be positively correlated with the increasing age of human subjects (r=.946, p<.01).

US$19.90

PMID: 9641258

DOI: 10.1016/s0891-5849(98)00010-0


Other references

Pirro RDe; Bertoli, A.; Greco, A.V.; Lauro, R., 1981: Transient effect of glucocorticoids on red blood cell insulin receptors. The effect of oral administration of dexamethasone or cortisone on circulating red blood cell (RBC) insulin receptors was evaluated in normal males before treatment and 24 h (day 1), 48 h (day 2) and 72 h (day 3) after the commencement of steroid...

Chung, Y.; Chang, S.Hee.; Martinez, G.J.; Yang, X.O.; Nurieva, R.; Kang, H.Soon.; Ma, L.; Watowich, S.S.; Jetten, A.M.; Tian, Q.; Dong, C., 2009: Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is critically required for the early programming of Th17 cell lineage and Th17 cell-mediated autoimmunity. IL...

Loman, A.Al.; Islam, S.M.Mahfuzul.; Li, Q.; Ju, L-Kwang., 2016: Soybean bio-refinery platform: enzymatic process for production of soy protein concentrate, soy protein isolate and fermentable sugar syrup. Soybean carbohydrate is often found to limit the use of protein in soy flour as food and animal feed due to its indigestibility to monogastric animal. In the current study, an enzymatic process was developed to produce not only soy protein concent...

Ochiai, Atsushi, 2001: A case of low grade malignant nasal hemangioendothelioma. Low grade malignant nasal hemangioendothelioma is very rare. A 62-year-old female presented with left nasal bleeding. A tumor was found in her left nasal cavity. The tumor was removed under local anesthesia and was diagnosed as a low grade maligna...

Dunn, K.E.; Saulsgiver, K.A.; Patrick, M.E.; Heil, S.H.; Higgins, S.T.; Sigmon, S.C., 2014: Characterizing and improving HIV and hepatitis knowledge among primary prescription opioid abusers. The high rates of HIV and Hepatitis C (HCV) infection among opioid abusers is a serious public health problem, and efforts to enhance knowledge regarding risks for HIV/hepatitis infection in this population are important. Abuse of prescription opi...

Lim, J-Min.; Jeon, C.Ok.; Jang, H.Hee.; Park, D-Jin.; Shin, Y.Kook.; Yeo, S-Hwan.; Kim, C-Jin., 2008: Albimonas donghaensis gen. nov., sp. nov., a non-photosynthetic member of the class Alphaproteobacteria isolated from seawater. A moderately halophilic Gram-negative bacterium, strain DS2(T), was isolated from seawater from the East Sea in Korea. Strain DS2(T) grew at salinities of 0-14% (w/v) NaCl and at temperatures in the range 10-38 degrees C. The cells were non-motile...

Frey, R.H., 1997: Bi-leaflet prosthetic heart valve. Official Gazette of the United States Patent & Trademark Office Patents 1196(1): 259, March 4

Jahnke, A.H.; Petersen, S.A.; Neumann, C.; Steinbach, L.; Morgan, F., 1992: A prospective comparison of computerized arthrotomography and magnetic resonance imaging of the glenohumeral joint. Twenty-five patients with shoulder instability or shoulder pain of undetermined etiology were prospectively evaluated with magnetic resonance imaging and computerized arthrotomography. Actual lesions were determined by arthroscopy or at the time o...

Wustenberghs, H.; Belmans, K.; Keulemans, J., 1996: The effect of summer pruning during the first leaf on the growth and flower bud formation of sweet cherries. Due to their highly pronounced apical dominance, sweet cherries branch poorly. However, after summer pruning, lateral buds are no longer dominated by the apical shoot and this may result in improved branching and/or enhanced flower bud formation....

Pradhan, A.; Pal, P.; Durocher, G.; Villeneuve, L.; Balassy, A.; Babai, F.; Gaboury, L.; Blanchard, L., 1995: Steady state and time-resolved fluorescence properties of metastatic and non-metastatic malignant cells from different species. Steady state and time-resolved fluorescence spectroscopy were employed to study the fluorescence from non-metastatic, metastatic and non-tumorigenic cell lines from different species. Excitations at 310 nm and 350 nm were used to monitor tryptopha...