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Functional immaturity in neonatal polymorphonuclear leukocytes of rhesus monkeys

, : Functional immaturity in neonatal polymorphonuclear leukocytes of rhesus monkeys. Journal Of Medical Primatology. 25(2): 84-88

Despite major advances in the management and care of critically ill and low-birthweight human and nonhuman primate infants over the past two decades, infection remains a major source of neonatal morbidity and mortality. Although the causes of enhanced susceptibility and dissemination of neonatal infections are incompletely defined in the literature, substantial evidence from this and other laboratories has implied that functional abnormalities of neonatal polymorphonuclear leukocytes (PMNs) may be a major contributor. Increased understanding of the functional characteristics of neonatal PMNs should, therefore, provide significant insight into the pathogenesis and possible therapy of infections in neonates. Our laboratory has been actively involved in evaluating the functional competence of PMNs in neonatal human and nonhuman primates. This report describes a study in which we have confirmed and characterized the functional compromises in neonatal PMNs of rhesus monkeys, including deficiencies in chemotaxis, membrane deformability, phagocytosis, and killing.


PMID: 8864979

DOI: 10.1111/j.1600-0684.1996.tb00199.x

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Abegaz, S.; Negussie, E.; Duguma, G.; Rege, J.E.O., 2002: Genetic parameter estimates for growth traits in Horro sheep. Variance components and genetic parameters were estimated for growth traits such as birth weight (BWT), weaning weight (WWT), 6-month weight (6MWT) and yearling weight (YWT) in indigenous Ethiopian Horro sheep using the average information REML (A...

Rudin S.; Bardfeld P.A.; Hart H., 1970: Magnifying multi hole collimators for the gamma ray camera systems. Journal of Nuclear Medicine 11(10): 641

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Gronemeyer, W., 1977: Norepinephrine instead of epinephrine in anaphylactic shock. Deutsche Medizinische Wochenschrift 102(3): 101-102

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Meschia, J.F.; Gwinn, K., 2009: Genetics in clinical trials. Frontiers of Neurology and Neuroscience 25: 152-157

Thygeson, P., 1959: A laboratory infection with adenovirus type 8 Laboratory and epidemiological observations. The first recognized case of accidental infection with adenovirus type 8 in a laboratory worker is reported. The infection resulted in typical epidemic keratoconjunctivitis and was confirmed by virus isolation and specific antibody response. In sp...

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