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General pharmacology of Regavirumab preparation (TI-23): (2) Effects on gastrointestinal system, smooth muscles, water and electrolyte excretion


, : General pharmacology of Regavirumab preparation (TI-23): (2) Effects on gastrointestinal system, smooth muscles, water and electrolyte excretion. Pharmacometrics 48(4): 259-265

A preparation containing human monoclonal antibody against cytomegalovirus (TI-23), was examined for effects on the gastrointestinal system, smooth muscles, water and electrolyte excretion and other physiological functions. Intravenous administration of 10, 30 or 100 mg/kg of TI-23 had no effect on the passage of a charcoal meal through the intestine in mice, on the peristalsis of the small intestine in rabbits or on gastric secretion in rats.

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