geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Genomic structure and complete sequence of the human FGFR4 gene


, : Genomic structure and complete sequence of the human FGFR4 gene. Mammalian Genome. 9(2): 131-135,.

We report the genomic structure and entire sequence of the fibroblast growth factor receptor 4 (FGFR4) gene. The gene spans approximately 11.3 kb. It is composed of 18 exons ranging in size from 71 bp to 600 bp. Exon-intron boundaries follow the GT/AG rule. Exon 1 is untranslated and preceded by structural elements characteristic of a TATA-free promoter. Although there are promoter motifs in intron 4 as well, there is currently no evidence of alternative transcription of FGFR4. Comparison of exon-intron boundaries of FGFR4 with those of FGFR1 and 3 reveals a remarkable degree of homology. With the exception of four, exon boundaries are at identical positions in all three receptor genes. Short tandem repeat polymorphisms (STRPs) were identified in introns 2 and 16 of FGFR4. The STRPs together with the sequence information will facilitate the rapid analysis of FGFR4 in those human disorders in which this gene can be considered a candidate.

US$19.90

PMID: 9457674

DOI: 10.1007/s003359900703


Other references

Cupic, V.; Jezdimirovic, M., 1995: Prophylaxis of postpartal paresis using drugs. Postpartal paresis or milch fever is one of the most frequent metabolic disorders in milch cows. The main cause of this condition is the release or elimination of minerals (calcium, magnesium, phosphorus) in colostrum and milk during partus. Detai...

Hetey L.; Quiring K., 1980: Synaptosomal uptake and release of dopamine and 5 hydroxy tryptamine in the nucleus accumbens in vitro following in vivo administration of lsd in rats. The uptake and the depolarization-induced release of dopamine (DA) and serotonin (5-HT) were investigated after systemic application of LSD on synaptosomes of the nucleus accumbens of rats. For the release experiments synaptosomes were prelabeled...

Abanda-Nkpwatt, D.K.imm, U.C.iner, H.; Schreiber, L.S.hwab, W., 2006: Plant volatiles can minimize the growth suppression of epiphytic bacteria by the phytopathogenic fungus Botrytis cinerea in co-culture experiments. Leaf surfaces of plants are colonized by microbes, although the ecological roles of most of these epiphytes are unknown. Eleven non-pathogenic bacteria were isolated from strawberry (Fragaria x ananassa) plants and tested for their ability to inte...

Ahlen, Lennart, 1964: Bird observations from the area of Letalven on the border between Narke and Vastergotland. Among others, breeding records of Alcedo atthis and occasional occurrences of Upupa epops, Turdus torquatus, Phoenicurus ochruros and Cocco-thraustes coccothraustes (several).

Sharma, V.M.; Shareef, M.M.; Bhaskar, K.; Kalidas, S.; Shetty, P.A.; Christopher, R.; Ramamohan, Y.; Pant, H.C.; Shetty, T.K., 2005: Nuclear localization of Munc18-1 (p67) in the adult rat brain and PC12 cells. Munc18-1, also referred to as p67, co-purifies with Cdk5 and has an important role in neurotransmitter release. The role of Munc18-1 for functional connectivity of the nervous system was demonstrated by gene knockout experiments in mice, wherein a...

Wendtner, C-M., 2013: Chemotherapy-free treatment of chronic lymphocytic leukemia?. Treatment of CLL patients with conventional cytotoxic agents is often combined with significant toxicity that prevents broad application especially in elderly patients. In addition, relapse frequently occurs after application of conventional chemo...

Slama G.; Klein J.C.; Tchobroutsky G., 1977: Nonminiaturized artificial pancreas for chronically dialyzed insulin dependent diabetic subjects. Diabetologia 13(4): 432-433

Abu-Diak, O.A.; Jones, D.S.; Andrews, G.P., 2012: Understanding the performance of melt-extruded poly(ethylene oxide)-bicalutamide solid dispersions: characterisation of microstructural properties using thermal, spectroscopic and drug release methods. In this article, we have prepared hot-melt-extruded solid dispersions of bicalutamide (BL) using poly(ethylene oxide) (PEO) as a matrix platform. Prior to preparation, miscibility of PEO and BL was assessed using differential scanning calorimetry...

Schaffer, C.B.; Campbell, R.; Abramowitz, S.I., 1983: Inpatient community meeting as an aid to psychiatric diagnosis. There is a growing evidence that the clinical distinction of schizophrenia from mania should be based on a multidimensional approach rather than on the presence of characteristic symptoms. In-patient community group meetings are rarely appreciated...

Zaady, E.; Offer, Z.Y., 2010: Biogenic soil crusts and soil depth; a long-term case study from the central Negev Desert highland. Wind-blown soil degradation is a major problem in arid regions. Biogenic soil crust consists of a dense growth of many small organisms covering bare desert soil surfaces in arid regions worldwide. These organisms perform essential services in the...