+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Histamine H3 receptors contribute to drinking elicited by eating in rats

, : Histamine H3 receptors contribute to drinking elicited by eating in rats. Physiology & Behavior 58(6): 1091-1097

A role for endogenous histamine and its H3 receptor subtype for mediating drinking elicited by eating was examined in adult male Sprague-Dawley rats. The i.p. injection of the H3 agonist R-alpha-methylhistamine (Ramh, 2.5 mg/kg) shortened the latency to initiate drinking and increased 1-h water intake in nondeprived rats freely eating pellets and drinking water. The ICV injection (through a surgically implanted chronic cannula) of 10 micrograms Ramh increased water intake; this Ramh-induced drinking was abolished by previous ICV injection of the H3 antagonist thioperamide (Th, 60 micrograms). For rats drinking and eating after 24-h food deprivation, s.c. Th inhibited drinking behavior: for example, 10 mg/kg Th s.c. delayed the latency to initiate drinking and inhibited 1-h water intake without inhibition of food intake. In contrast, 60 micrograms Th ICV failed to inhibit food-related drinking in rats eating after food deprivation. For nondeprived rats eating a small cracker, 10 mg/kg Th s.c. delayed the latency to initiate drinking and abolished water intake without effect of eating, and 60 micrograms Th ICV had similar effects upon drinking elicited by ingestion of cracker. The IG infusion (through a surgically implanted gastric catheter) of 2 ml 600 or 900 mOsm/kg NaCl, a treatment that is subthreshold for increase in systemic plasma osmolality at the initiation of drinking, elicited drinking that was abolished by 10 mg/kg Th s.c. and attenuated by 60 micrograms Th ICV. The IG infusion of 2 ml 1800 mOsm/kg NaCl, a treatment that is above threshold for increase in systemic plasma osmolality, elicited drinking that was attenuated by 10 mg/kg s.c. or 60 micrograms Th ICV. These results demonstrate that peripheral and central H3 receptors for histamine have a role in drinking elicited by eating and the postprandial gastrointestinal osmotic consequences of eating. These findings extend the evidence demonstrating a histaminergic contribution to food-related drinking in rats.


PMID: 8623007

DOI: 10.1016/0031-9384(95)02048-9

Other references

Beldean, P., 2004: The suprafamily Pentatomoidea Insecta, Heteroptera in Cheile Runcului Nature Reserve Alba county, Romania Suprafamilia Pentatomoidea Insecta, Heteroptera in zona rezervatiei Cheile Runcului Jud Alba, Romania. Studia Universitatis Babes-Bolyai Biologia, 492: 11-17

Koroleva, I.V.; Khlebodarova, T.M.; Rubtsov, N.B.; Zakiian, S.M., 1994: Mapping the silver fox genome. IV. Determination of chromosomal location of genes for ornithine carbamoyltransferase and prion protein. The location in chromosomes of genes encoding ornithine carbamoyltransferase (ornithine transcarbamylase, OTC) and prion protein (PrP) was determined by Southern blotting of DNAs obtained from a panel of hybrid (for x Chinese hamster) somatic cell...

Mok, J.Y.; Simpson, H., 1984: Outcome for acute bronchitis, bronchiolitis, and pneumonia in infancy. The clinical and respiratory function characteristics of 200 children 7 years after their admission to hospital with acute lower respiratory tract infection in infancy have been presented. Results were subsequently analysed according to disease ca...

Evans, F.A.; Strang, J.M., 1932: Basal metabolism changes during the dietary correction of under-nutrition. 11 patients with severe under-nutrition were treated by dietary measures alone and gained on the average 1070 g. per person per week for 5.4 weeks: the average total gain was 5.8 kg., equivalent to 14 per cent. of the average initial weight. There...

Stephens, M.; Palakal, M.; Mukhopadhyay, S.; Raje, R.; Mostafa, J., 2001: Detecting gene relations from Medline abstracts. Research in bioinformatics in the past decade has generated a large volume of textual biological data stored in databases such as MEDLINE. It takes a copious amount of effort and time, even for expert users, to manually extract useful information...

Wattanapisit, A.; Fungthongcharoen, K.; Saengow, U.; Vijitpongjinda, S., 2016: Physical activity among medical students in Southern Thailand: a mixed methods study. The study aimed to investigate the prevalence of physical activity (PA) and factors influencing PA behaviours among medical students in Southern Thailand. The study implemented a mixed methods approach. The sequential design consisted of 2 phases:...

Dann, T.C.; James, D.R., 1982: Carcinoma of the tongue. Report of a case in a 24-year-old man. Practitioner 226(1363): 144-145

Kettner, M.; Schnabel, A.; Ramsthaler, F., 2013: Suspected paradoxical undressing in a homicide case. Paradoxical undressing is a phenomenon associated with fatalities due to severe hypothermia, which is characterized by the act of active undressing, despite low ambient temperatures, as a consequence of peripheral vasodilation. A 51-year-old man w...

Anonymous, 1959: A patient with a liver lesion. Nederlands Tijdschrift Voor Geneeskunde 103(12): 621-623

Fedotov, V.P.; Rynkova, N.N., 1966: Inactivation of 17-oxycorticosteroids in the liver of healthy dogs and in dogs exposed to ionizing radiation. Experiments on angiostomized dogs were made to study the capacity of the liver to inactivate corticosteroids. The intensity of retention of free 17-oxycorticosteroids by the liver was estimated from the difference in their level in the blood colle...