+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Human papillomavirus type 18 associates with more advanced cervical neoplasia than human papillomavirus type 16

, : Human papillomavirus type 18 associates with more advanced cervical neoplasia than human papillomavirus type 16. Human Pathology. 24(4): 432-437

A type-specific, sensitive, polymerase chain reaction-based assay for human papillomavirus (HPV) types 6b, 11, 16, 18, and 33 was applied to 47 cervical carcinomas, 60 cases of cervical intraepithelial neoplasia (CIN), and 24 samples of histologically normal cervix. As expected, the combined incidence of the common high-risk genital HPVs (types 16 and 18) was high in carcinomas (79%) and CIN 2/3 (60%), low in CIN 1 (25%), and nonexistent in the normal controls. Analysis of the data by viral type and pathology revealed statistically significant differences that consistently pointed to an association of HPV 18 with more advanced disease than HPV 16. This was exemplified by calculation of the relative HPV frequency in squamous cancers and CIN 2/3 lesions, which gave cancer to CIN prevalence ratios of 1.2 for HPV 16 and 2.3 for HPV 18, a twofold difference suggesting the possibility that there is a greater risk of progression or a more rapid transition to malignancy associated with HPV 18. Furthermore, HPV 16 was associated with 2.5-fold more cancers showing squamous differentiation (58%) than HPV 18 (23%), but both types showed an identical prevalence of 41% in the clinically more sinister adenocarcinomas, indicating that there may be an association between HPV type and cancer cell differentiation.


PMID: 8387954

DOI: 10.1016/0046-8177(93)90093-v

Other references

Bayer, E.A.; D.M.ester, F.; Kulik, T.; Wilchek, M., 1995: Preparation of deglycosylated egg white avidin. A simple procedure for the preparation of deglycosylated avidin is described. Commercially obtained avidin was treated with a mixed microbial culture. The cells were capable of growing on the oligosaccharide residues, but generally ignored the pol...

Wu, C.C.; Shih, C.H.; Chen, W.J.; Tai, C.L., 1999: Treatment of ununited femoral shaft fractures associated with locked nail breakage: comparison between closed and open revision techniques. To investigate and compare closed and open revision techniques in the treatment of ununited femoral shaft fractures associated with locked nail breakage. Retrospective. University hospital. Ununited femoral shaft fractures associated with locked n...

Lau, J.T.F.; Yang, X.; Tsui, H.Y.; Pang, E.; Wing, Y.Kwok., 2005: Positive mental health-related impacts of the SARS epidemic on the general public in Hong Kong and their associations with other negative impacts. Objectives: To investigate 2 positive impacts (better family/social support and lifestyle changes) and their associations with other negative impacts. Study design and participants: A telephone survey using random telephone numbers and a structure...

Law, M.; Russell, D.; Pollock, N.; Rosenbaum, P.; Walter, S.; King, G., 1997: A comparison of intensive neurodevelopmental therapy plus casting and a regular occupational therapy program for children with cerebral palsy. The purpose of this research was to evaluate the combined effect of intensive neurodevelopmental therapy (NDT) and casting in improving hand function, quality of upper-extremity movement and range of motion in children aged between 18 months and 4...

Pinsky, P.F., 2014: Re: prostate cancer mortality in areas with high and low prostate cancer incidence. Journal of the National Cancer Institute 106(10): -

Hendriks, W.L.; van der Boom, H.; van Vark, L.C.; Havekes, L.M., 1996: Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophages. Lipoprotein lipase (LPL) stimulates the uptake of low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) in different cell types, including macrophages, through bridging of LPL between lipoproteins and extracellular heparan sulphate...

Attia, M.S.; Ramsis, M.N.; Khalil, L.H.; Hashem, S.G., 2012: Spectrofluorimetric assessment of chlorzoxazone and ibuprofen in pharmaceutical formulations by using Eu-tetracycline HCl optical sensor doped in sol-gel matrix. A novel, simple, sensitive and selective spectrofluorimetric method was developed for the determination of trace amounts of chlorzoxazone and Ibuprofen in pharmaceutical tablets using optical sensor Eu-Tetracycline HCl doped in sol gel matrix. The...

Wilson, W.W.; Koo, W.W.; Smaaladen, T., 1984: Grain transportation rates and export market development. This study (which summarizes Smaaladen's thesis) analyzes the effectiveness of using rail rate reductions for export market development. A base model is developed to depict spatial distribution, which is determined by the quantities of a comm...

Sfikas, P.M., 2001: Beyond the AwDA. Journal of the American Dental Association 132(9): 1304-1306

Holm, R.P., 2014: Patient education: Oh! We got trouble. South Dakota Medicine 67(1): 36-36