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IL-10 Prevents naturally occurring fetal loss in the CBA times DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau


, : IL-10 Prevents naturally occurring fetal loss in the CBA times DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. Journal of Immunology 154(9): 4261-4268

CBA times DBA/2 placentae are quantitatively or qualitatively deficient in their production of the anti-inflammatory Th2-type cytokines IL-4- and IL-10 compared with the nonresorption-prone CBA times BALB/c mating combination. Wastage in this mating combination is accompanied by increased levels of local inflammatory cytokines. In addition, alloimmunization enhances the placental production of IL-4 and IL-10 in CBA times DBA/2 matings. Furthermore, rIL-10 by itself completely reverses the high incidence of fetal resorption after i.p. injection. Conversely, anti-IL-10 increases the resorption rate, but only in CBA times DBA/2 matings. On the other hand, injecting either anti-IFN-gamma or pentoxifylline (an anti-TNF agent) partially reduces the resorption. When given together, they produce a synergistic remission of fetal loss. Finally, we report that recombinant ovine trophoblast protein, an IFN-tau which is known to influence reproductive outcome in ruminants, can also counteract increased CBA times DBA/2 fetal resorption. It simultaneously induces increased placental IL-4 and IL-10 production in this mating combination. These results indicate that the placentally produced anti-inflammatory cytokines can play a vital role in the survival to term of the fetal allograft, by counteracting deleterious inflammatory cytokines.

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Other references

Dixon, K., 1998: Enough already! Myths and realities of managed behavioral health care. Behavioral Healthcare Tomorrow 7(1): 37-41

Hampton, J.R., 1990: Secondary prevention of acute myocardial infarction with beta-blocking agents and calcium antagonists. The discovery that beta blockers possess clinically useful hypotensive, antianginal and antiarrhythmic properties has attracted the interest of clinicians, researchers and the pharmaceutical community alike. In addition, minor differences in a var...

Zvirbul' , A.P., 1981: Measurements of aerial fertilizer applications to forests with conical traps. Traps were used to determine the proportion of fertilizer reaching target areas, the distribution of granules on the ground between projected crown, canopy gaps and the area close to the stem for different species and the number of traps necessary...

Campbell, P.M., 1995: 1995 Edward H. Angle research prize. Angle Orthodontist 65(6): 386-386

Wilson M.E., 1975: Microbiological proficiency what basis for confidence. Prier, James E , Josephine Bartola And Herman Friedman (Ed ) Quality Control in Microbiology Symposium Philadelphia, Pa , U S A Nov 15-16, 1973 X+188p Illus University Park Press: Baltimore, Md , U S A ; London, England Isbn 0-8391-0766-8 119-122

Rizzoli, Ré.; Reginster, J-Yves.; Boonen, S.; Bréart, Gérard.; Diez-Perez, A.; Felsenberg, D.; Kaufman, J-Marc.; Kanis, J.A.; Cooper, C., 2011: Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. The pharmacological management of disease should involve consideration of the balance between the beneficial effects of treatment on outcome and the probability of adverse effects. The aim of this review is to explore the risk of adverse drug reac...

Decker, George C., 1943: Toxic-dust barriers for chinch bug control. A continuous line of a toxic dust approx. 1 inch wide applied on a smooth surface between infested grain fields and corn was effective in controlling chinch bugs (Blissus leucopterus) by killing all nymphs and adults that attempted to cross the li...

Schnur, R.E.; Wick, P.A.; Bailey, C.; Rebbeck, T.; Weleber, R.G.; Wagstaff, J.; Grix, A.W.; Pagon, R.A.; Hockey, A.; Edwards, M.J., 1994: Phenotypic variability in X-linked ocular albinism: relationship to linkage genotypes. One hundred nineteen individuals from 11 families with X-linked ocular albinism (OA1) were studied with respect to both their clinical phenotypes and their linkage genotypes. In a four-generation Australian family, two affected males and an obliga...

Dechkov, Z., 1984: The potential infestation of soils by weed seeds in the Veliko Turnovo region. Data on the soil infestation by seeds of 32 weed spp. in the Veliko Turnovo region of Bulgaria are given.

Guseinov, G.A., 1954: The effectiveness of therapy of ascariasis with santonin of a species of wormwood. Cats having Toxocara infestation were given santonin from Artemisia transiliensis (AT). Ten mg/kg administered on 2 successive days caused the elimination of Toxocara in 9 cats of 10, and 4 of these were completely cured. Two-hundred-thirty patien...