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Immunohistochemical analysis of thyroid adenomas with Hurthle cells


, : Immunohistochemical analysis of thyroid adenomas with Hurthle cells. Pathology 30(1): 4-6

Twenty-five cases of thyroid adenomas with Hurthle cell changes, both pure and focal, were studied histologically and immunohistochemically with two objectives: first to elucidate the relationship between the normal uninvolved thyroid and the adenoma; and second, to evaluate the role of immunohistochemical studies in adenomas with Hurthle cell changes. Representative sections were stained with a panel of nine antibodies directed against thyroglobulin (TG), high molecular weight keratin (HMK), low molecular weight keratin (LMK), p53, bcl-2, epithelial membrane antigen (EMA), S100, carcinoembryonic antigen (CEA) and HMB45. In all cases, uniform strong positive staining (+ + +) with TG and bcl-2 was seen in the normal thyroid tissue while the adenoma stained moderately positive (+ +). The reverse pattern was observed with LMK staining. Non-adenomatous thyroid cells were p53-negative, the majority of the Hurthle cells, however, were p53-positive and adenomas with an increased number of Hurthle cells had an increased percentage of p53 staining. The expression of EMA was variable. All thyroid cells both outside and within the adenoma were S100-, CEA-4 and HMB45-negative in all cases. The exact significance of p53 overexpression in the Hurthle cells needs further evaluation.

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PMID: 9534199


Other references

Rieder, J., 1988: Bekannte und neue Befunde betreffend die Gattungen Cyclophrya und Heliophrya Protozoa, Suctoria. Exact diagnoses, completed in comparison to those formerly obtainable, are given for the two genera mentioned and all of their species and subspecies actually known, including two newly described. New information on "birth" and metamorph...

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Taran, Yuri A.; Peiffer, Loic, 2009: Hydrology, hydrochemistry and geothermal potential of El Chichon volcano-hydrothermal system, Mexico. Fluid and heat discharge rates of thermal springs of El Chichon Volcano were measured using the chloride inventory method. Four of the five known groups of hot springs discharge near-neutral Na-Ca-Cl-SO4 waters with a similar composition (Cl appro...

Hackett, L.K.; Tarsa, M.; Wolfson, T.J.; Kaplan, G.; Vaux, K.K.; Pretorius, D.H., 2010: Use of multiplanar 3-dimensional ultrasonography for prenatal sex identification. Determination of fetal sex is an important part of detailed second-trimester ultrasonography. This task can be hindered by the fetal position, a low amniotic fluid volume, and advanced gestational age. Identification of fetal sex is further import...

L.R.lle, A-France.; Klempner, S.J.; Garrett, C.R.; Seery, T.; Sanford, E.M.; Balasubramanian, S.; Ross, J.S.; Stephens, P.J.; Miller, V.A.; Ali, S.M.; Chiu, V.K., 2016: Identification and characterization of RET fusions in advanced colorectal cancer. There is an unmet clinical need for molecularly directed therapies available for metastatic colorectal cancer. Comprehensive genomic profiling has the potential to identify actionable genomic alterations in colorectal cancer. Through comprehensive...

Kosel, Vladimir, 2004: Taxonomical position of two species of Trocheta (Hirudinea) described from Central Europe. The paper deals with the nomenclatural status of the leech species Trocheta cylindrica described by Orley in 1886 from the Slovakian Carpathians. The taxon was rejected by Apathy in 1888 and forgotten. In 1998, the locus typicus of T. cylindrica w...

Cayo-Quiñe, A.; Bustamante-Voysest, R.; Martínez-Vargas, V., 2015: A shocking cystory. Clinical Gastroenterology and Hepatology 12(5): E39-E40

Battistuzzi, P.G.F.C.M.; Lombroso, C., 2010: The criminal according to Cesare Lombroso. Nederlands Tijdschrift Voor Tandheelkunde 117(9): 425-425

Hsiao, K-Chih.; Crawford, B., 2007: Still room for improvement in our handover practices. New Zealand Medical Journal 120(1255): U2568-U2568

Brass L.M.; Merikangas K.R.; Robinette C.D., 1990: A twin study of stroke. Annals of Neurology 28(2): 256