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Immunohistochemical and electrophysiological evidence for omega-conotoxin-sensitive calcium channels in unmyelinated C-fibres of biopsied human sural nerve

, : Immunohistochemical and electrophysiological evidence for omega-conotoxin-sensitive calcium channels in unmyelinated C-fibres of biopsied human sural nerve. Brain Research 723(1-2): 29-36

In vitro electrophysiological measurements of Ca-2+ potentials in human sural nerve fascicles revealed that Ca-2+ conductances might be present on unmyelinated C-fibres. Furthermore, these Ca-2+ potentials were partially blocked by omega-conotoxin, a calcium antagonist for the N-type Ca-2+ channels. Therefore, immunohistochemical staining with indirect immunofluorescent omega-conotoxin GVIA was used to localize N-type Ca-2+ channels in intact and in enzymatically dissociated human sural nerve fascicles. Densities of toxin binding sites were highly heterogeneous throughout the different nerve fascicles investigated and putative N-type Ca-2+ channels were localized in about 20% of the unmyelinated C-fibres. Myelinating Schwann cells as well as enzymatically demyelinated axons displayed no specific binding indicating the absence of N-type Ca-2+ channels.


PMID: 8813379

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