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Immunohistochemical and histochemical evidence for the presence of noradrenaline, serotonin and gamma-aminobutyric acid in chief cells of the mouse carotid body


, : Immunohistochemical and histochemical evidence for the presence of noradrenaline, serotonin and gamma-aminobutyric acid in chief cells of the mouse carotid body. Cell & Tissue Research. 278(2): 249-254

The immunohistochemical study revealed tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT), serotonin, glutamate decarboxylase (GAD) and gamma-aminobutyric acid (GABA) immunoreactivities in the mouse carotid body. TH and DBH immunoreactivities were found in almost all chief cells and a few ganglion cells, and in relatively numerous varicose nerve fibers of the carotid body. The histofluorescence microscopy showed catecholamine fluorescence in almost all chief cells. However, no PNMT immunoreactivity was observed in the carotid body. Serotonin, GAD and GABA immunoreactivities were also seen in almost all chief cells of the carotid body. From combined immunohistochemistry and fluorescence histochemistry, catecholamine and serotonin or catecholamine and GABA were colocalized in almost all chief cells. Thus, these findings suggest that noradrenaline, serotonin and GABA may be synthesized and co-exist in almost all chief cells of the mouse carotid body and may play roles in chemoreceptive functions.

US$19.90

PMID: 8001081

DOI: 10.1007/bf00414167


Other references

Vetter, H.F., 1959: Fatal isonicotinic acid hydrazide poisoning. (Suicide with 10g INH). Die Medizinische 44: 2117-2118

Melloni, E.; Pontremoli, S.; Viotti, P.L.; Patrone, M.; Marks, P.A.; Rifkind, R.A., 1989: Differential expression of protein kinase C isozymes and erythroleukemia cell differentiation. Hexamethylene bisacetamide (HMBA) and other polar/apolar chemical agents are potent inducers of erythroid differentiation in murine erythroleukemia cells (MELC), as well as other transformed cell lines. Although the mechanism of action of HMBA is...

Arneodo, J.; de Breuil, S.; Lenardon, S.; Conci, L., 2005: Natural infection of Viola cornuta (Violaceae) with Cucumber mosaic virus, subgroup I. Plants of Viola cornuta displaying typical virus symptoms were observed during spring 2003 in a plant nursery in Cordoba, central Argentina. Electron microscopic examinations of symptomatic leaf samples revealed the presence of isometric virus-lik...

Walling Desmond E.; Owens Philip N.; Leeks Graham J.L., 1998: The role of channel and floodplain storage in the suspended sediment budget of the River Ouse, Yorkshire, UK. This study attempts to quantify the amount of fine-grained (ca. <150 mu m) sediment stored on the floodplains and on the channel bed of the non-tidal sections of the main channels in the catchment of the River Ouse (3315 km (super 2) ) and of o...

Anonymous, 2012: Estudios Craneometricos en el Craneo de la Gacela del Tibet Procapra Picticaudata. A total of 10 skulls of Tibetan gazelle were utilized in this study. Craniometric measurements for 22 different parts of the skull were made. Skull indices and ratios were calculated. A skull index of 43.22 0.44, a cranial index of 58.37 0.80 and...

Wickramasinghe S.N., 1972: Kinetics and morphology of hemopoiesis in pernicious anemia. British Journal of Haematology 22(2): 111-115

Satuito, CG.; Hirayama, K., 1991: Supplementary effect of vitamin C and squid liver oil on the nutritional value of baker's yeast for the population growth of the rotifer Brachionus plicatilis. Bulletin of the Faculty of Fisheries Nagasaki University, 7-11 No. 69

Hurster, M., 1984: The Queens Modified Area Health Education Center. Journal of Allied Health 13(3): 191-196

Kondo, S.; Toyokuni, S.; Tanaka, T.; Hiai, H.; Onodera, H.; Kasai, H.; Imamura, M., 2000: Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is one of the most abundant oxidatively modified lesions in DNA. Our previous study (Kondo et al, Free Radic. Biol. Med., 27: 401-410, 1999) revealed that human colorectal carcinoma cells are oxidatively s...

Badham J.P.N.; Robinson B.W.; Morton R.D., 1972: The Geology and Genesis of the Great Bear Lake Silver Deposits. Precambrian Echo Bay Group, vein type U-Ag-Ni, Co arsenides-Bi deposits, fault zones, paragenesis, temperature of formation, genesis, Canada.