+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical and ultrastructural study of hepatic sinusoidal linings during dichloropropanol-induced acute hepatic necrosis

, : Immunohistochemical and ultrastructural study of hepatic sinusoidal linings during dichloropropanol-induced acute hepatic necrosis. Liver. 14(2): 90-97

An acute phase of severe hepatic necrosis induced by dichloropropanol was examined immunohistochemically and ultrastructurally, in order to study chronological changes of sinusoidal morphology during acute hepatic injury. Male Wistar rats were injected with 1,3-dichloro-2-propanol (DC2P) and sacrificed at various intervals after the injections. DC2P-injected rats showed zonal necrosis of the centrilobular space with a peak from 24 to 48 h after the injection. Destruction of sinusoidal linings appeared at 4 h, and was gradually aggravated along the advancing hepatocytic necrosis. Monocytic influx into the necrotic areas was initiated at 6 h. At 48 h, collapsed centrilobular spaces showed a loss of most sinusoidal structures with active phagocytosis of macrophages, proliferation of perisinusoidal cells, and accumulation of collagen fibrils. At 72 h, there were many regenerating sinusoidal structures, which were composed of rather thick and less fenestrated endothelium and underlying multilayered processes of mesenchymal cells, along the regenerating hepatocytes. In these areas, occasional junctions between regenerating hepatocytes and mesenchymal cells were seen. Reconstruction of sinusoidal linings was closely related to the hepatocytic regeneration, and a hepatocytic-mesenchymal interaction might participate in this morphodynamic course of the sinusoidal reconstruction.


PMID: 8196516

DOI: 10.1111/j.1600-0676.1994.tb00054.x

Other references

Nishikawa, M.; Sekitani, T.; Nishikawa, K.; Yagi, M.; Ohyama, H.; Okuzono, T.; Noguchi, T.; Hiyoshi, M., 1981: The image of CT-scan and artifact on the unilateral paranasal sinusitis--with a preliminary report of phantom study. Nihon Jibiinkoka Gakkai Kaiho 84(4): 408-412

Lee, G.; Wong, D.Y.; Chang, R.C., 1992: Hemangiopericytoma of the parotid gland: report of case. Journal of Oral and Maxillofacial Surgery 50(12): 1329-1332

Hallet, J.; Beyfuss, K.; Memeo, R.; Karanicolas, P.J.; Marescaux, J.; Pessaux, P., 2016: Short and long-term outcomes of laparoscopic compared to open liver resection for colorectal liver metastases. Minimally invasive surgery (MIS) is now established as standard of care for a variety of gastrointestinal procedures for benign and malignant indications. However, due to concerns regarding superiority to open liver resection (OLR), the uptake of...

Ezcurra, I.; Ellerstrom, M.; Stalberg, K.; Rask, L., 1995: Functional analysis and binding properties of a Cis-element in the napin promoter. Journal of Cellular Biochemistry Supplement 0(21A): 463

Neff, N.H.; Podell, M.; Hadjiconstantinou, M., 2003: Feline Parkinson disease model MRI and MRS identifies structural and biochemical changes after MPTP. Journal of Neurochemistry 85(Supplement 1): 40, May

Peck H.; Pollitt R.J., 1979: Occurrence of gamma glutamyl phenyl alanine in the urine of new born phenyl ketonurics. The urine of unrelated [human] phenylketonurics in the 1st wk of life contains .gamma.-glutamylphenylalanine (0.07-0.69 mmol/g creatinine, 12 samples) visible on the normal 2-dimensional electrophoreto-chromatogram. This compound is less prominent...

Kozyts'-Kyi, Im, 1970: Analytical studies on distributi. Zemlerobstvo 4 36-40

Leon, D.A.; Pablo-Casas, J.; Dale, C.; Polikina, O.; Tomkins, S.; McKee, M., 2010: Re: "Alcohol consumption in young adults and incident hypertension: 20-year follow-up from the Coronary Artery Risk Development in Young Adults Study". American Journal of Epidemiology 172(6): 743-4; Authors Reply 744-5, 746

Albertano P.; Taddei R., 1984: Chlorella protothecoides var acidicola new variety from very low ph environments. The presence of C. protothecoides Kruger is recorded in highly acid environments (up to pH = 1.0) from which 12 strains were isolated. A comparative examination of these and other strains of the same species, but from different sources, showed tha...

Nakagawa, Y.; Ohzeki, T., 2008: Genetic regulation of the biosynthesis of steroid hormones. Steroid hormones play the critical roles in human. Glucocorticoid is indispensable for the life. Mineralocorticoid regulates the balance of electrolytes. Androgen and estrogen are necessary for sexual development. In the biosynthesis of steroid ho...