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Immunohistochemical characterisation of the costochondral junction in SIDS

, : Immunohistochemical characterisation of the costochondral junction in SIDS. Journal of Clinical Pathology 46(2): 108-112

Aim: To characterise the distribution of major growth plate proteoglycan in a group of infants who died of SIDS. Methods: Nine such infants and eight age matched controls were selected from the necropsy files at the Adelaid Children's Hospital. Sections of rib and adjacent costal cartilage were stained for chondroitin-4-sulphate, chondroitin-6-sulphate, and keratan sulphate with antibodies 2-B-6, 3-B-3, and 5-D-4, respectively, using standard techniques. Results: The distribution of proteoglycans within the extracellular matrix of the costochondral junction in the group of SIDS infants was identical with that found in control infants. Conclusion: Any changes present in the growth plate in cases of SIDS are most likely caused by secondary phenomena.


PMID: 8459029

DOI: 10.1136/jcp.46.2.108

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