geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical characteristics of colorectal carcinoma with DNA replication errors


, : Immunohistochemical characteristics of colorectal carcinoma with DNA replication errors. Journal of Korean Medical Science 11(2): 137-143

It has recently been shown that nearly all cancers from hereditary nonpolyposis colorectal cancer syndrome (HNPCC), as well as a subset of sporadic colorectal cancers, have DNA replication errors (RER) at repeated sequences distributed throughout their genome. These RER-positive cancers had pathological characteristics of more frequent exophytic growth, large size and poor differentiation. However, the histogenesis and immunohistochemical characteristics of these RER-positive cancers are not known. The poorly differentiated colorectal carcinomas are heterogenous group of neoplasms that differ in their histologic appearance and prognosis. We therefore examined RER from 69 sporadic colorectal carcinomas of poor differentiation and detected in 23 cases (33%). The pathological features of RER-positive cancers differed from those without RER. The RER-positive cancers had marked preponderance of proximal location (16/23, 70%, vs. 20/46, 43%, p < 0.04), no glandular differentiation with intense peritumoral immune response (12/23, 52% vs. 6/46, 13%, p < 0.001). Immunohistochemically, most of the RER-positive cancers were reactive for cytokeratin (22/23, 96%) and CEA (17/23, 74%), and negative for NSE (2/23, 9%), chromogranin (3/23, 13%) and synaptophysin (0/23, 0%). In comparison to 46 RER-negative tumors, RER-positive cancer had less frequent CEA expression (17/23, 74% vs. 44/46, 96%, p = 0.01). We conclude that the RER-positive colorectal carcinomas have histologic characteristics of predominantly solid, poorly differentiated adenocarcinomas with intense peritumoral reaction and the tumors should be distinguished from neuroendocrine carcinomas and other more aggressive non-glandular tumors of the colon.

US$19.90

PMID: 8835761

DOI: 10.3346/jkms.1996.11.2.137


Other references

Cox, G.W.; Melillo, G.; Sheffler, L.A.; Willis, J.D.; Varesio, L., 1994: Inhibition of proliferation of immortalized mouse macrophages by cytokines and nitric oxide. FASEB Journal 8(4-5): A510

Toma, B.D.ret, C.C.appuis, G.P.llerin, B., 1979: Failure of immunisation against infectious peritonitis in the cat by injection of porcine transmissible gastroenteritis virus. Recueil de medecine veterinaire 155(10): 799-803

Jäger, M.; Strauss, A.; Frasch, K.; Becker, T., 2007: Conceptual foundation of the operational diagnostic approach in psychiatry. Based on the pioneering work of Emil Kraepelin, Karl Jaspers, Kurt Schneider and representatives of logical empiricism, the basic principles of the operational diagnostic approach in psychiatry are described. Operational diagnostic systems like IC...

Weigand D.A.; Burgdorf W.H.C.; Gregg L.J., 1981: Dermal mucinosis in discoid lupus erythematosus 2 cases. Two patients with discoid lupus erythematosus (DLE) had lesions exhibiting prominent atrophy and telangiectasia. At the time of biopsy the skin specimens were grossly mucinous. Light and immunofluorescence microscopy findings confirmed the diagnos...

Boudet, M.J.; Perniceni, T., 1998: Inguinal hernia treatment. Efficacy of groin hernia repair is mainly evaluated by its recurrence rate. In the literature it depends on the type of surgery but also on the follow-up, which must last 5 years at least and has to be more than 90% complete. To acertain the clini...

Wilson, N.F.; Iyer, J.Kannan.; Buchheim, J.A.; Meek, W., 2008: Regulation of flagellar length in Chlamydomonas. Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). Durin...

Rahman, A.; Nakasone, A.; Chhun, T.; Ooura, C.; Biswas, K.Kanti.; Uchimiya, H.; Tsurumi, S.; Baskin, T.I.; Tanaka, A.; Oono, Y., 2006: A small acidic protein 1 (SMAP1) mediates responses of the Arabidopsis root to the synthetic auxin 2,4-dichlorophenoxyacetic acid. 2,4-dichlorophenoxyacetic acid (2,4-D), a chemical analogue of indole-3-acetic acid (IAA), is widely used as a growth regulator and exogenous source of auxin. Because 2,4-D evokes physiological and molecular responses similar to those evoked by IA...

Francis, M.P.; Duffy, C., 2005: Length at maturity in three pelagic sharks (Lamna nasus, Isurus oxyrinchus, and Prionace glauca) from New Zealand. Reproductive data collected from porbeagle, shortfin mako, and blue sharks caught around New Zealand were used to estimate the median length at maturity. Data on clasper development, presence or absence of spermatophores or spermatozeugmata, uteru...

Vila, J.; Simon, K.; Ruiz, J.; Horcajada, J.P.; Velasco, M.; Barranco, M.; Moreno, A.; Mensa, J., 2002: Are quinolone-resistant uropathogenic Escherichia coli less virulent?. The prevalence of hemolysin, type 1 fimbriae, P fimbriae, cytotoxic necrotizing factor-1 (CNF-1), aerobactin, and autotransporter toxin (sat) was analyzed by polymerase chain reaction and phenotypic assays of 42 epidemiologically unrelated Escheri...

Cima, R.F.F.; van Breukelen, G.; Vlaeyen, J.W.S., 2017: Tinnitus-related fear: Mediating the effects of a cognitive behavioural specialised tinnitus treatment. Cognitive behavioural treatments (CBT) for the reduction of tinnitus complaints have been shown to be effective; however the specific mechanisms of change are yet to be unveiled. Reductions in tinnitus-related fear have been indicated to be an imp...