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Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinomas of the head and neck


, : Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinomas of the head and neck. Otolaryngology - Head & Neck Surgery 113(5): 541-549

This study was designed to investigate the presence of nitric oxide in human squamous cell carcinoma of the head and neck. We localized the activity of nitric oxide synthase in these tumors through immunohistochemical analysis using antibodies to L-Citrulline (a byproduct of nitric oxide synthase), to inducible nitric oxide synthase, and to constitutive nitric oxide synthase. We found presence of inducible enzyme in squamous cells throughout these tumors, with the highest intensity staining occurring directly around keratin pearls. Our findings suggest that inducible nitric oxide synthase activity is present in squamous cell carcinomas of the head and neck, loading us to conclude that inducible nitric oxide synthase may play a significant role in tumor growth.

US$29.90

PMID: 7478643


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Bernardini, G.; Figura, N.; Ponzetto, A.; Marzocchi, B.; Santucci, A., 2017: Application of proteomics to the study of Helicobacter pylori and implications for the clinic. Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the gastric epithelium and mucous layer of more than half the world's population. H. pylori is a primary human pathogen, responsible for the development of chronic ga...

Thomas Hess, C., 2010: Checklists for compliance. Advances in Skin & Wound Care 23(4): 192-192

Monti, B.; Berteotti, C.; Contestabile, A., 2005: Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear. Rolipram, a type IV-specific phosphodiesterase inhibitor, is known to improve memory under various learning tasks. Moreover, Rolipram treatments have been shown to increase expression and phosphorylation of a key factor for hippocampal memory cons...

Barba, L., 2010: Achieving progress from the ground up. Behavioral Healthcare 30(1): 48-48

Collin, T.; Jeffery, S.; Reid, C., 2006: Bath-water scalds in children and thermostatic mixer valves. Scalds in children caused by hot bath-water have been virtually eliminated in countries where thermostatic mixer valve (TMV) devices have been introduced. We aimed to determine the frequency and severity of these injuries in our region and estimat...

Yang, J.; Brodland, G.Wayne., 2009: Estimating interfacial tension from the shape histories of cells in compressed aggregates: a computational study. A 3D cell-based finite element (FE) model is used to show that the tensions postulated to act along cell-cell interfaces can be determined from tests in which an aggregate of cells is compressed between parallel plates. The aspect ratios kappa of...

Tubiana M., 1967: Duration of the cellular cycle during evolution of an experimental ascites in mice neopl tumor. Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences Serie D Sciences Naturelles1: 829-832

Hards V.L., 1993: The evolution of the Snaefell volcanic centre, eastern Iceland. 1(1): 45 1993

Singer, M.I.; Blom, E.D.; Hamaker, R.C., 1985: Vocal rehabilitation after laryngectomy. The evolution of treatment of laryngeal cancer has passed a number of milestones. The maintenance of useful communication is of paramount importance in all cases and, with the newer modalities of tracheoesophageal phonation and voice prostheses, t...

Lemieux, S.; Weisnagel, S.J.; Piche, M.E.; Bergeron, J.; Nadeau, A., 2002: Plasma free fatty acid suppression in response to hyperinsulinemia in postmenopausal women. International Journal of Obesity 26(Supplement 1): S78, August