geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical comparative investigations of lymphatic tissue in reactive processes, myasthenic thymuses and Hodgkin's disease


, : Immunohistochemical comparative investigations of lymphatic tissue in reactive processes, myasthenic thymuses and Hodgkin's disease. Archivum Immunologiae et Therapiae Experimentalis 43(1): 15-22

In this study coexpression of cytokeratin and desmin, and occasionally also Ki-1 antigen, was displayed in extrafollicular reticulum cells of reactive lymph nodes. The absence or expression of trace amounts of these proteins in normal lymphoid tissue suggests that activation of T cell regions is correlated with the increased frequency of cytokeratin, desmin and Ki-1-expressing cells, and therefore may be a transient phenomenon. S-100-positive interdigitating reticular cells were found occasionally in extrafollicular T cell region of normal lymph nodes. They were, however, more numerous in reactive lymphatic tissue. In the myasthenic thymuses cells forming Hassall's corpuscles displayed coexpression of cytokeratin, desmin and Ki-1 antigen. Medullary epithelial cells were also cytokeratin-positive and, additionally, Ki-1 antigen was expressed on some cells dispersed in whole thymic tissue. S-100-positive interdigitating reticular cells were especially numerous in the thymic medulla and some of them were found inside the Hassall's corpuscles. In Hodgkin's disease deficiency of cytokeratin and desmin in extrafollicular reticulum cells is a constant phenomenon in spite of a classic inflammatory background. However, Ki-1 antigen displayed Reed-Sternberg cells which, similar as some thymic cell elements, appear to originate from stromal perivascular mesenchyme. This fact suggests that Reed-Sternberg cells in Hodgkin's disease are pathologic counterparts of extrafollicular reticulum cells which represent a cellular differentiation defect to produce desmin and cytokeratin but with a possibility of Ki-1 antigen expression. The consequence of this may be the dysregulation of immune system and the observed immunologic abnormalities. Further studies are needed to elucidate the role of Epstein-Barr viruses in this process. S-100-positive interdigitating reticular cells were in close contact with Reed-Sternberg cells and they were especially large and with numerous cells processes in the mixed cellularity (MC) subtype. The occurrence of interdigitating reticulum cells with S-100 protein expression, especially numerous in the T cell region activated of peripheral lymphatic tissue, as well as their close contact with Reed-Sternberg cells and with cells forming Hassall's corpuscles suggest their eventual possible role in the function of the immune system.

US$29.90

PMID: 8744679


Other references

Lamport, Kurt., 1908: Tiere und Pflanzen der Jetztzeit in unseren Hohlen. Tubingen Bl Albver, 20 11-19, 50-54, 74-80

Miller, David, 1938: The vitamins of the B-G complex. The nomenclature of the vits. of the B-G complex is discussed in the light of recent developments and the important events in its resolution are described in charts and tables. The role of the chicken as an experimental animal in the development o...

Weintraub, M.; Hasday, J.D.; Mushlin, A.I.; Lockwood, D.H., 1984: A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination. We performed a double-blind, controlled clinical trial comparing phentermine resin (30 mg in the morning), fenfluramine hydrochloride (20 mg three times a day), and a combination of phentermine resin (15 mg in the morning) and fenfluramine hydroch...

Liu, Y.; Liu, Y.; Sun, C.; Gan, L.; Zhang, L.; Mao, A.; Du, Y.; Zhou, R.; Zhang, H., 2015: Correction: Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF. Plos One 10(8): E0135508-E0135508

Gilles, Gl, 1973: Use of the biological test in the study of replantation problems in fruit culture. Fruit belge: th Quarter 41 (364) 284-288

Kumar, M.; Senden, T.; Sheppard, A.; Arns, C.; Knackstedt, M., 2010: Variations in the Archies exponent; probing wettability and low Sw effects. Petrophysics (Houston, Tex.) 51.2

Majdak, E.Joanna.; Debniak, J.; Milczek, T.; Cornelisse, C.J.; Devilee, P.; Emerich, J.; Jassem, J.; D.B.ck, G.Hendrika., 2005: Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma. BACKGROUND. The clinical relevance of BRCA1/2 alterations in ovarian carcinoma patients is debatable. Our aim was to determine factors influencing the risk of recurrence and death in ovarian carcinoma patients with BRCA pathogenic and unclassified...

Fraccaro, M.; Mannini, A.; Tiepolo, L.; Gerli, M.; Zara, C., 1968: Karyotyping clonal evolution in a cystic adenoma of the ovary. Lancet 1(7543): 613-614

Swales Andrew; Oldman John W.; Smith Keith, 2006: Bedform geometry on a barred sandy shore. An instrumented sled was used to repeatedly measure nearshore profiles and bedform height (eta ), length (lambda ) and asymmetry (alpha ) on a double-barred beach at Mangawhai (Northland, New Zealand). The 6-week experiment measured cross-shore pr...

Cowen, E.L.; Wyman, P.A.; Work, W.C.; Iker, M.R., 1995: A preventive intervention for enhancing resilience among highly stressed urban children. Describes the development and evaluation of a pilot 12-session, school-based preventive intervention designed to enhance resilience among inner-city children who have experienced major life stress. Thirty-six 4th-6th grade children participated in...