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Immunohistochemical demonstration of alpha-fetoprotein in small hepatocellular carcinoma


, : Immunohistochemical demonstration of alpha-fetoprotein in small hepatocellular carcinoma. Oncology Reports 5(2): 355-358

We demonstrated immunohistochemical staining of alpha-fetoprotein (AFP) in small hepatocellular carcinoma (HCC). Fifty-six patients with HCC less than 2 cm in diameter were studied. Twenty-five HCCs (44.6%) were positive for AFP-staining. The positive rate of AFP-staining in HCC tissue was higher in the patients with serum AFP concentration above 20 ng/ml than that of the patients with below 20 ng/ml. AFP-staining was demonstrated on the rough endoplasmic reticulum of HCC cells by immuno-electron microscopy. AFP-staining of tissue specimens obtained by fine needle biopsy is useful in the histologic diagnosis of HCC.

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PMID: 9468556


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