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Immunohistochemical demonstration of expression of tyrosine hydroxylase in cerebellar Purkinje cells of the human and mouse


, : Immunohistochemical demonstration of expression of tyrosine hydroxylase in cerebellar Purkinje cells of the human and mouse. Neuroscience Letters. 165(1-2): 161-163

We demonstrated the expression of tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT) in cerebellar Purkinje cells of human and mouse brains by immunohistochemistry. At the age of 8 months, vermal Purkinje cells in the human cerebellum were immunoreactive with anti-TH or anti-human specific PNMT antiserum. We also found TH-positive Purkinje cells in the mouse brain. TH immunoreactivity first appeared in the Purkinje cells in the caudal vermis from postnatal day 8 (P8), and enlarged numbers between P13 and P15. After gradual reduction to P19, the TH-positive Purkinje cells again multiplied the number from the age of 4 weeks, and maintained in a large number up to old stage. At the age of 11 months, the other groups of TH-positive Purkinje cells appeared in the flocculus and paraflocculus of the mouse cerebellum.

US$19.90

PMID: 7912416

DOI: 10.1016/0304-3940(94)90734-X


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