+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of DNA topoisomerase IIalpha, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer

, : Immunohistochemical detection of DNA topoisomerase IIalpha, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer. British Journal of Cancer 77(9): 1469-1473

Non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) differ significantly in their clinical response to topoisomerase IIalpha (topo-IIalpha)-directed drugs, such as etoposide and teniposide, as NSCLC is virtually insensitive to single-agent therapy, while SCLC responds in two-thirds of cases.


PMID: 9652763

Other references

Darboux J.R.; Plusquellec Y., 1981: Lower Devonian tectonics of the Crozon Peninsula; the Capucins Section, Roscanvel, Armorican Massif, France. Comptes-Rendus des Seances de l'Academie des Sciences, Serie 2: Mecanique-Physique, Chimie, Sciences de l'Univers, Sciences de la Terre 292(20): 1409-1411

Jacklet J., 1977: Protein synthesis requirement for an endogenous circadian rhythm in neuronal activity. Journal of General Physiology 70(6): 10A-11A

Uhrstrom, I., 1969: The time effect of auxin and calcium on growth and elastic modulus in hypocotyls. In studies of the relationship between Young's modulus and longitudinal growth in sunflower hypocotyl segments, the results confirmed that one of the primary actions of auxin is to loosen the cell-wail matrix. Ca always increased Young's...

Karlen B., 1977: An example of enzymic hydroxylation alpha to an acetylenic group. Xenobiotica: 95

Watanabe, C.T.; Rosenblatt, J.D.; Bakker, A.; Morgan, J.P.; Luo, J.; Chun, S.; Black, A.C., 1996: Negative regulation of gene expression from the HTLV type II long terminal repeat by Rex: functional and structural dissociation from positive posttranscriptional regulation. Regulation of human T cell leukemia virus type II (HTLV-II) gene expression by Rex is mediated by cis-acting elements in the 5' viral long terminal repeat (LTR). Rex acts posttranscriptionally to enhance cytoplasmic accumulation of incomplete...

Kiernan, C.M.; Weiss, V.L.; Mehrad, M.; Ely, K.; Baregamian, N.; Solórzano, C.C., 2017: New terminology-noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) and its effect on the rate of malignancy at a single institution. The cytologic qualities of noninvasive follicular neoplasm with papillary-like nuclear features mimic papillary thyroid carcinoma (PTC) on fine-needle aspiration, leading to difficulty in distinguishing the 2 preoperatively. The aim of this study...

Schinz, A.; Schnelle, K.; Klein, G., 1978: Mode of action of cardiovascular drugs. Echocardiographic studies. Echocardiography--combined with additional non-invasive methods--has proved a sensitive tool for measuring hemodynamic and left ventricular function parameters. This study was undertaken to measure by these methods the effect of digoxin, isoproter...

Semenza, G., 1967: Rate equations of some cases of enzyme inhibition and activation--their application to sodium-activated membrane transport systems. The rate equations reported in the present paper refer to the rapid equilibrium kinetics of the following 2 models 1 substrate, 2 modi-fiers competing for the same modifier site; 1 modifier, 2 substrates competing for the same substrate site. Case...

Dick, T.E.; Hengst, J.A.; Fox, T.E.; Colledge, A.L.; Kale, V.P.; Sung, S-Shu.; Sharma, A.; Amin, S.; Loughran, T.P.; Kester, M.; Wang, H-Gang.; Yun, J.K., 2015: The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. We previously developed SKI-178 (N'-[(1E)-1-(3,4-dimethoxyphenyl)ethylidene]-3-(4-methoxxyphenyl)-1H-pyrazole-5-carbohydrazide) as a novel sphingosine kinase-1 (SphK1) selective inhibitor and, herein, sought to determine the mechanism-of-acti...

Menezes, I., 1989: Arterial hypertension in diabetes mellitus. Etiopathogenesis and treatment. The different aspects of the etiopathogenesis of arterial hypertension in diabetes mellitus are reviewed. Therapeutic approaches and the several phases of treatment are discussed, with particular emphasis on the most recent developments.