geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of E-cadherin in differentiated thyroid carcinomas correlates with clinical outcome


, : Immunohistochemical detection of E-cadherin in differentiated thyroid carcinomas correlates with clinical outcome. Cancer Research 57(12): 2501-2507

A retrospective immunohistochemical analysis of the adhesion molecule E-cadherin (E-CD) was performed in 112 differentiated thyroid carcinomas and 38 synchronous and 20 relapse metastases primarily from operations performed at the Medical School Hanover between 1982 and 1992. E-CD-specific antibody 5H9 was applied to paraffin-embedded tissues. All patients were clinically followed for a maximal period of 12 years. Lack of E-CD expression i.e., <5% of tumor cells positive) occurred in 18 of 112 (16.1%) cases, whereas the majority showed either low (24.1%), medium (35.7%), or high (24.1%) positivity. No difference was found between papillary (n = 88) and follicular (n = 24) carcinomas. Univariate statistical analysis for survival (Kaplan-Meier) showed that lack of E-CD expression (P < 0.024) is an adverse prognostic factor for differentiated thyroid carcinomas. The highest significance was seen among patients without lymph node involvement at first presentation (pN(0); P = 0.0068) and among females (P = 0.0033). Multivariate analysis (Cox model) indicated that E-CD staining is an independent prognostic factor (corrected risk factor, 3.7; P < 0.03) in addition to distant metastasis (pM1) and tumor size. A comparison of E-CD stainings between primary tumors and their metastatic lesions showed similar results in both synchronous and relapse metastases after therapy. In conclusion, E-CD immunostaining is an independent prognostic indicator for differentiated thyroid carcinomas. It may help to uncover the small group of patients with differentiated thyroid carcinomas carrying a high risk of suffering an unfavorable clinical outcome.

US$29.90

PMID: 9192832


Other references

Anonymous, 2012: The development of organization of medical care to patients with degenerative dystrophic diseases of lumbosacral section of spine. The article deals with issues of development of organizational technologies in the field of medical care of patients with degenerative dystrophic diseases of lumbosacral section of spine. The comprehensive evaluation of the process of medical care...

Brandhagen, D.J.; Feldt, R.H.; Williams, D.E., 1991: Long-term psychologic implications of congenital heart disease: a 25-year follow-up. Patients with various types of congenital heart disease were contacted 25 years after their original examination at the Mayo Clinic. In addition to providing their current health status, level of education achieved, and current occupation, they we...

Kleinberg, D.L.; Barcellos-Hoff, M.Helen., 2012: The pivotal role of insulin-like growth factor I in normal mammary development. Mammary development begins in puberty in response to an estrogen (E(2)) surge. E(2) does not act alone. It relies on pituitary growth hormone (GH) to induce insulin-like growth factor I (IGF-I) production in the mammary stromal compartment. In tur...

Scott, M.A.; Davis, J.M.; Schwartz, K.A., 1994: A new immunoradiometric assay for canine platelet-associated immunoglobulin. Blood 84(10 SUPPL 1): 187A

Fan, H.; Hui, J.; Duan, Z.; Fan, D.; Mi, Y.; Deng, J.; Li, H., 2015: Novel scaffolds fabricated using oleuropein for bone tissue engineering. We investigated the feasibility of oleuropein as a cross-linking agent for fabricating three-dimensional (3D) porous composite scaffolds for bone tissue engineering. Human-like collagen (HLC) and nanohydroxyapatite (n-HAp) were used to fabricate t...

Henquin J.C.; Meissner H.P.I., 1981: Influence of the sodium potassium pump on resting membrane potential and electrical activity of mouse beta cells. Diabetologia 21(3): 281

Burton, J.D.; Smith, D.M., 1972: Guying to prevent wind sway influences Loblolly Pine growth and wood properties. Eight dominant 19-year-old trees of Pinus taeda in S. Arkansas were paired on the basis of height growth; one tree from each pair was guyed at 18 and 32 ft above ground in 1958. Stem analyses after 4 years showed that restraining young trees from...

Colvine A.C., 1978: Early Precambrian porphyry deposits. Ontario Geological Survey Miscellaneous Paper: ages 216-217. 1978.

Dahl, A.O., 1970: Two hybrid hollies. The cultivars John T. Morris and Lydia T. Morris are sister seedlings from a cross between Ilex cornuta and I. pernyi. Both cultivars exhibit the pyramidal habit of I. pernyi and the dense branching of I. cornuta.

McCuaig T.C.mpbell; Kerrich Rob; Xie Qianli, 1994: Phosphorus and high field strength element anomalies in Archean high-magnesian magmas as possible indicators of source mineralogy and depth. Two suites of late Archean ( nearly equal 2.7 Ga) high-MgO rocks in the Yilgarn Block, Western Australia and the Superior Province, Canada display negative P anomalies relative to Pr and Nd on primitive mantle normalized diagrams. In contrast, mos...