geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of MUC2 mucin core protein in ulcerative colitis


, : Immunohistochemical detection of MUC2 mucin core protein in ulcerative colitis. Journal Of Clinical Laboratory Analysis. 12(3): 150-153

MUC2 mucin is predominantly expressed in the colon and is considered to play an important role in the protection of that organ. Recent findings suggested that MUC2 protein levels are significantly decreased in active ulcerative colitis (UC). We therefore performed an immunohistochemical study to reveal if the expression of MUC2 protein is altered in UC. Seventy-nine biopsy tissue specimens from 31 UC patients, along with normal colon tissues, were immunostained with anti-MUC2 mucin core protein monoclonal antibody (MoAb) CCP58 (IgG1). UC tissue specimens were divided into two groups based on the histological severity of inflammation, i.e., 64 with active inflammation (grades 2-5) and 15 without (grade 1). In the former group, 52 out of 64 (81.3%) tissue specimens contained sections of glands with a few cells positive for MoAb CCP58. These glands were small and consisted of MUC2 negative-short cells and a few positive cells without apparent mucus formation, considered to be immature regenerative glands. In contrast, the staining pattern was almost the same as that of the normal colon and no immature glands were seen in the group without active inflammation. The sections of immature regenerative glands with a few MUC2-positive cells were exclusively found in the UC tissues with active inflammation, but not in those without it, suggesting that the expression of MUC2 protein may be decreased in active UC.

US$19.90

PMID: 9591701

DOI: 10.1002/(sici)1098-2825(1998)12:3<150::aid-jcla4>3.0.co;2-d


Other references

Gast, M.J., 1996: The evolution of new agents for ovulation induction. The field of clinical ovulation-induction therapy has remained relatively static for over 30 years. This field promises to benefit from advances in our understanding of the biology of ovulation, and from exciting new work in the areas of molecular...

Rogers, L.; Reibman, J., 2012: Pharmacologic approaches to life-threatening asthma. Following a peak in asthma mortality in the late 1980s and early 1990s, we have been fortunate to see a substantial decrease in asthma deaths in recent years. Although most asthma deaths occur outside the hospital, near-fatal events are commonplac...

Vineyard Jerry D., 1974: Hahatonka geology field trip MVOR, September 14, 1974. The Ozark Speleograph 4(3): 80-107

Pierre, C.; Carloz, E.; Marlier-Civatte, M.; Branquet, D.; Gros, P., 1995: Pseudo-parasites in histology and cytopathology. When interpreting smears and specimens, histologists and cytopathologists can be misled by images which mimic microorganisms, especially protozoans, mycotic agents or helminths. Although some of these pitfalls are well-known, others can be problem...

Mescon, Herbert, 1966: Disturbances of hair and nails. Current Pediatric Therapy: -1967 563

El-Sharkawy, H.; Tahoun, A.; El-Gohary, A.El-Galiel.A.; El-Abasy, M.; El-Khayat, F.; Gillespie, T.; Kitade, Y.; Hafez, H.M.; Neubauer, H.; El-Adawy, H., 2017: Epidemiological, molecular characterization and antibiotic resistance of iSalmonella enterica serovars isolated from chicken farms in Egypt. <i>Salmonella</i> is one of major causes of foodborne outbreaks globally. This study was conducted to estimate the prevalence, typing and antibiotic susceptibilities of <i>Salmonella enterica</i> serovars isolated from 41 b...

Mokwa Robert L.; Duncan J.M.chael, 2001: Experimental evaluation of lateral-load resistance of pile caps. Although pile caps have considerable ability to resist lateral loads, this resistance is often neglected in design. Published cases involving a variety of pile and cap sizes, soil conditions, and loading conditions indicate that the lateral-load r...

Debski, E.A.; Friesen, W.O., 1985: Habituation of swimming activity in the medicinal leech. Tactile stimulation (light stroking) of a body wall flap attached to the ventral nerve cord of the medicinal leech evokes episodes of swimming activity. This swimming response undergoes habituation, involving changes in swim initiation and swim ma...

Pirmukhamedova M.N., 1980: Nonspecific immunity indices during chronic entero colitis in children. Serum complement and lysozyme were studied in 80 children with chronic enterocolitis of varying severity, in whose complex treatment protein hydrolysates were used. High complement and lysozyme levels were not observed before or after treatment. A...

Paull, C.K.; Hecker, B.; Commeau, R.; Freeman-Lynde, R.P.; Neumann, C.; Corso, W.P.; Golubic, S.; Hook, J.E.; Sikes, E.; Curray, J., 1984: Biological communities at the Florida escarpment resemble hydrothermal vent taxa. Dense biological communities of large epifaunal taxa similar to those found along ridge crest vents at the East Pacific Rise were discovered in the abyssal Gulf of Mexico. These assemblages occur on a passive continental margin at the base of the...