+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of P-glycoprotein in Ewing's sarcoma and peripheral primitive neuroectodermal tumors before and after chemotherapy

, : Immunohistochemical detection of P-glycoprotein in Ewing's sarcoma and peripheral primitive neuroectodermal tumors before and after chemotherapy. American Journal of Clinical Pathology 102(1): 61-67

The authors evaluated P-glycoprotein expression in a total of 35 cases of Ewing's sarcoma and peripheral primitive neuroectodermal tumors (PNET). Fifteen cases had matched tumors before and after treatment. The 20 unmatched tumors included 14 pretreatment PNETs and Ewing's sarcomas and 6 posttreatment Ewing's sarcomas. Two antibodies, C219 and JSB-1, were used. Immunoreactivity was almost exclusively membranous. Variability in the number of positive cells and in staining intensity was noted within individual tumors. Among the 15 matched tumors, 7 were positive for P-glycoprotein before treatment; 6 of these remained positive after treatment. Four of the 8 that were negative for P-glycoprotein before treatment became positive after treatment. Of the unmatched tumors, 9 of 14 pretreatment and 3 of 6 posttreatment tumors were positive. When relapse-free survival time, based on the presence or absence of P-glycoprotein positivity in pretreatment tumor samples, was evaluated in this group, no significant difference was found (P-2 = .92); however, the numbers are too small to draw definitive conclusions. The high incidence of positive primary tumors suggests that P-glycoprotein expression is probably intrinsic in Ewing's sarcoma and PNET and not necessarily induced by therapy.


PMID: 7913576

DOI: 10.1093/ajcp/102.1.61

Other references

Ismail, M.Fouad., 2007: Pulmonary metastatic melanoma. Journal of Thoracic and Cardiovascular Surgery 134(4): 1097-1097

Doyle, A.G.; Jacobsen, E.N., 2005: Enantioselective alkylations of tributyltin enolates catalyzed by Cr(salen)Cl: access to enantiomerically enriched all-carbon quaternary centers. The catalytic asymmetric alpha-alkylation of tributyltin enolates with a range of primary alkyl halides is catalyzed by a chiral Cr(salen) complex. The reaction constitutes the first transition-metal-catalyzed system for alpha-alkylation of carbon...

Kratz, C.R., 1974: Two methodological problems. Nursing Times 70(33): Suppl:53-6

Palson, E., 1948: The importance of sexual health control in artificial insemination. In Sweden the artificial insemination program includes complete health control, pregnancy examination and sterility treatment. In some districts nearly all herds are supervised by trained and specialized veterinarians. Pregnancy examination is car...

Cervera, N.; Itzykson, R.; Coppin, E.; Prebet, T.; Murati, A.; Legall, S.; Vey, N.; Solary, E.; Birnbaum, D.; Gelsi-Boyer, Véronique., 2014: Gene mutations differently impact the prognosis of the myelodysplastic and myeloproliferative classes of chronic myelomonocytic leukemia. Initially classified in the myelodysplastic syndromes (MDSs), chronic myelomonocytic leukemia (CMML) is currently considered as a MDS/myeloproliferative neoplasm. Two classes-myelodysplastic and myeloproliferative-have been distinguished upon the...

Kabasakal, H.; Kabasakal, E., 2004: Species of Rissoidea (Gastropoda: Prosobranchia) collected from the northern coast of Edremit Bay and from Bozcaada (northeastern Aegean Sea). Thirteen rissoideans, representing 3 families, were recorded from the coasts of Bozcaada and Edremit Bay. Descriptions of the examined shells with brief notes on their distribution and ecology are presented.

Waterhouse, R.N.; Mardon, K.; O'brien, J.C., 1997: Synthesis and preliminary evaluation of 1- -4- -oxy-methylpiperidine A novel high affinity sigma receptor radioligand for SPECT. 1-(4-Cyanobenzyl)-4-(((trans-iodopropen-2-yl)oxy)methyl)piperidine (2) has been synthesized as a novel iodinated ligand for sigma receptors. This new compound exhibited high affinity (K-i = 0.38 nM) for the sigma-1 receptor and selectivity for sig...

Stevens, P.A.; Harrison, A.F.; Jones, H.E.; Williams, T.G.; Hughes, S., 1993: Nitrate leaching from a Sitka spruce plantation and the effect of fertilisation with phosphorus and potassium. Mature Sitka spruce (Picea sitchensis (Bong.) Carr.) plantations in the Beddgelert area of North Wales have comparatively large concentrations and leaching rates of soil water nitrate. To determine whether elimination of any phosphorus or potassiu...

Galardo, A.Kardec.Ribeiro.; Galardo, Cícia.Denis.; Silveira, G.Abbad.; Ribeiro, K.Augusto.Nabas.; Hijjar, Aéa.Valadão.; Oliveira, L.Leite.; Dos Santos, T.Vasconcelos., 2016: Phlebotominae sand flies (Diptera: Psychodidae): potential vectors of American cutaneous leishmaniasis agents in the area associated with the Santo Antônio Hydroelectric System in Western Amazonian Brazil. An entomological study was conducted as part of a vector-monitoring program in the area associated with the Santo Antônio hydroelectric system in State of Rondônia, Western Amazonian Brazil. Fourteen sampling sites were surveyed to obtain data o...

Bernstein, R.; Leigh, S.; Siegel, M.; Donovan, S., 2002: IGF-I bioavailability and patterns of body size variation. American Journal of Physical Anthropology Supplement (34): 44