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Immunohistochemical detection of bcl-2 and MIB-1/Ki-67 in breast cancer: retrospective analysis of 238 cases

, : Immunohistochemical detection of bcl-2 and MIB-1/Ki-67 in breast cancer: retrospective analysis of 238 cases. Medicina 56(3): 252-258

We considered of interest to determine the possible interrelationship between the proliferation-related marker MIB-1/Ki-67 and the bcl-2, a protein involved in the blockage of apoptosis, and whether they contributed to the prognosis of breast cancer. For this purpose we carried out a retrospective immunohistochemical study of 238 cases of stage I and II breast carcinomas with a follow up of at least 5 years. The study revealed that high expression of MIB-1 was associated with high nuclear and histological grades (p < 0.001 for both), negative estrogen receptor status (p = 0.009) and progesterone status (p = 0.004), and younger age (p = 0.014). High bcl-2 expression was associated with smaller tumor size (p = 0.001), positive estrogen and progesterone receptors (p < 0.001 for both); low nuclear grade (p < 0.001), low histological grade (p < 0.002), stage I disease (p = 0.01) and low MIB-1 expression (p = 0.025). The univariate Cox regression showed a significant association of high MIB-1 expression (p = 0.002) and low bcl-2 expression (p = 0.04) with shorter OS. Furthermore, MIB-1 expression was a significant independent predictor of OS (p = 0.002) as showed by stepwise Cox regression analysis.


PMID: 9035481

Other references

Smulikowski W.; Teisseyre H., 1973: The crag called Tower NE Miedzygorze; mutual relation of Gieraltow- and Snieznik-type gneisses. Pages 184-185 1973

Guggenheim S.; Kato T., 1984: Kinoshitalite and Mn phlogopites; trial refinements in subgroup symmetry and further refinement in ideal symmetry. Mineralogical Journal 12(1): 1-5

Kathiresan, S., 1969: Morphological studies on the thymus. I. Thymus of the marsupial--Trichosurus vulpecula. Indian Journal of Medical Research 57(5): 939-943

Massey E.W.; Donaldson J.O., 1988: Femoral neuropathy following vaginal delivery. Neurology 38(3 SUPPL 1): 206

Kelly W.R.; Paulsen P.J., 1984: Determination of sulfur in NBS coals by isotope dilution thermal ionization mass spectrometry. National Bureau of Standards Special Publication 260-94: 7-13

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