geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of nitrotyrosine in postischemic cerebral cortex in gerbil


, : Immunohistochemical detection of nitrotyrosine in postischemic cerebral cortex in gerbil. Neuroscience Letters. 235(1-2): 85-88,. 10

We examined whether or not nitration of tyrosine residues takes place in the ischemic and postischemic reperfused brain. The nitration of tyrosine residues to produce nitrotyrosine is a sensitive marker elicited by peroxynitrite, a powerful oxidant formed by the reaction of nitric oxide (NO) with superoxide. Mongolian gerbils were subjected to 60 min ischemia induced by occlusion of the right common carotid artery (ischemia group), to 30 min recirculation following 60 min ischemia (reperfusion group) or to sham surgery (sham group). Immunohistochemical staining with polyclonal anti-nitrotyrosine antibody revealed the widespread and distinct occurrence of nitrotyrosine in cortical neurons on the reperfused side of the brain in the reperfusion group, while only partial or weak immunoreactivity was noted on the contralateral side. On the other hand, nitrotyrosine was not detected in the brain of the ischemia and sham groups. These findings suggest that nitration of tyrosine residues in various proteins may be closely associated with reperfusion injury of the brain.

US$19.90

PMID: 9389602

DOI: 10.1016/s0304-3940(97)00725-8


Other references

Vicat, J-Paul.; Doumnang Mbaigane, J-Claude.; Bellion, Y., 2014: Contents of macromineral and trace elements in spirulina (Arthrospira platensis) from France, Chad, Togo, Niger, Mali, Burkina-Faso and Central African Republic. Data on mineral elements in spirulinas being limited, we analyzed macrominerals and trace elements of samples from France and Africa. Spirulinas cultivated in France have a composition in macromineral elements similar to those of the literature. T...

Turvey, M., 1945: Work in a leper colony in South Africa. Nursing Times 41: 722-722

Payne W.S., 1991: How extensive should myotomy be?. Giuli, R , R W Mccallum And D B Skinner Primary Motility Disorders Of The Esophagus: 450 Questions - 450 Answers Lxxv+1217p John Libbey Eurotext: Paris, France; London, England, Uk Illus 919-923

Black, D.W.; Gabel, J.; Hansen, J.; Schlosser, S., 2001: A double-blind comparison of fluvoxamine versus placebo in the treatment of compulsive buying disorder. Nondepressed outpatients with a compulsive buying disorder were recruited by advertisement and word of mouth for inclusion in a controlled treatment trial. Following a 1-week single-blind placebo washout, subjects were randomly assigned to fluvoxa...

Jaroszyński, W.; Keslinka, E.; Wujtewicz, M.; Suchorzewska, J.; Kwiatkowski, Błomiej., 2002: Effect of hydroxyethyl starch (HAES) on degree and kinetics of erythrocyte aggregation studied with dielectric spectroscopy method. Colloidal fluids, e.g. hydroxyethyl starch (HAES), used as blood plasma substitutes during acute controlled normovolemic hemodilution may cause erythrocyte aggregation. The aim of the presented study was to assess the degree and rate of erythrocyt...

Bittebierre, J., 2013: Reduction of the diffraction in strongly resonant thin-film Fabry-Perot filters between single-mode fibers. Simulations show that the cumbersome diffraction losses occurring in narrow bandpass thin-film Fabry-Perot filters (TF-FP filters) inserted between two narrow-core optical fibers are strongly reduced by introducing into the filter a pair of film m...

Yadav, M.K.; Leeneshwar, H.; Jai, R.P., 2007: Pulseless cardiomyopathy. Takayasu arteritis can have myriads of presentation, depending on site and extent of disease. As no age is immune for this disease, it is important to keep a high index of suspicion, otherwise the diagnosis can be missed. We hereby describe a case...

Chew, W.Fong.; Leong, P.Pooi.; Yap, S.Fan.; Yasmin, A.Malik.; Choo, K.Bung.; Low, G.Kim.Kuan.; Boo, N.Yun., 2017: Risk factors associated with abdominal obesity in suburban adolescents from a Malaysian district. We aimed to determine the risk factors associated with abdominal obesity (AO) in suburban adolescents. This cross-sectional study included adolescents aged 15-17 years from five randomly selected secondary schools in the Hulu Langat district of Se...

Kerr, W.C.; Greenfield, T.K., 2015: Racial/Ethnic Disparities in the Self-Reported Number of Drinks in 2 Hours Before Driving Becomes Impaired. We used data on self-reported impaired driving and the number of drinks the person states he or she can have in 2 hours before impairment to evaluate predictors of individuals' impairment thresholds by race/ethnicity. Data come from the 2000,...

Garrick, D.J., 2002: Dairy cow improvements using selection and crossbreeding. Animal improvement schemes in practice are all about compromise. In selection, there needs to be compromise between the progress in individual traits that contribute to the objective, and compromise in terms of the rate of progress in relation to...