geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of p53 protein expression in mammary carcinoma: a study of 80 cases


, : Immunohistochemical detection of p53 protein expression in mammary carcinoma: a study of 80 cases. Pathology 27(4): 365-369

Overexpression of p53 protein appears to be a common event in primary mammary carcinoma. This study was performed on 80 primary carcinomas of varying type and grade. Tumor p53 protein expression was detected by means of immunohistochemistry using the monoclonal antibody DO7 on formalin fixed paraffin-embedded tissue sections. p53 overexpression was found in 50 (63%) of the 80 tumors. The correlation between p53 expression and high tumor grade, presence of in situ component and lymphocytic response was significant. However, no significant association was found between p53 expression and tumor size, age of the patients or tumor vascular invasion. Our study suggested that the immunohistochemical assay was a simple method of detection of mutant p53 proteins in routinely processed paraffin-embedded tissues of primary mammary carcinoma.

US$29.90

PMID: 8771158


Other references

Strickland, R., 1996: C.I. Lewis and Deming's theory of knowledge. W. Edwards Deming's theory of management has had significant impact on the way managers have understood their role in recent times. An important influence on his philosophy was the work of C.I. Lewis in an area of philosophy known as epistemo...

DeShong, H.L.; Tucker, R.P.; O'Keefe, V.M.; Mullins-Sweatt, S.N.; Wingate, L.R., 2015: Five factor model traits as a predictor of suicide ideation and interpersonal suicide risk in a college sample. Research has demonstrated an inconsistent relationship between suicide ideation and personality traits. This is the first study to empirically examine the relationship of the Five Factor Model of personality with current, past and no suicide ideat...

Hubener, H.J.; Maurer, H.; Walther, T., 1953: Simple differentiation method for precise flame-photometric determination of the blood calcium. Klinische Wochenschrift 31(45-46): 1095-1096

Bonner, K.F.; Daner, W.; Yao, J.Q., 2011: 2-year postoperative evaluation of a patient with a symptomatic full-thickness patellar cartilage defect repaired with particulated juvenile cartilage tissue. This case report describes the early results of a 36-year-old man who underwent repair of a symptomatic full-thickness patellar cartilage defect with transplanted particulated juvenile articular cartilage. At 2 years postoperatively, the patient h...

Swindell, W.R., 2008: Genes regulated by caloric restriction have unique roles within transcriptional networks. Caloric restriction (CR) has received much interest as an intervention that delays age-related disease and increases lifespan. Whole-genome microarrays have been used to identify specific genes underlying these effects, and in mice, this has led t...

Thelen, E.; Farish, D.J., 1977: An analysis of the grooming behavior of wild and mutant strains of bracon hebetor braconidae hymenoptera. Grooming behavior in the wild type parasitic wasp B. hebetor and 10 mutant strains was observed and the grooming movements recorded by a keyboard which activated clocks and an event recorder. The 15 distinct fixed action patterns [FAD] used by B....

Bernard, J.L.; Scheiner, C.; Devaux, J.; de Rocca-Serra, P.; Bonerandi, J.J.; Gentet, J.C.; Raybaud, C., 1986: Spontaneously regressive benign cutaneous histiocytosis X in newborn infants. Presse Medicale 15(24): 1157-1157

McIlhany; McKeown; Meissner; Menden; Metz; Meyners; Mikloukho; Miller; Miller; Milner; Most; Muccifora; Naryshkin; Nathan; Neunreither; Niczyporuk; Nowak; O'Neill; Openshaw; Ouyang; Owen; Pate; Potashov; Potterveld; Rakness; Redwine, 2000: Measurement of the spin asymmetry in the photoproduction of pairs of high- p(T) hadrons at HERMES. We present a measurement of the longitudinal spin asymmetry A(||) in photoproduction of pairs of hadrons with high transverse momentum p(T). Data were accumulated by the HERMES experiment using a 27.5 GeV polarized positron beam and a polarized hy...

Scalzi, H.A., 1967: The cytoarchitecture of gustatory receptors from the rabbit foliate papillae. Zeitschrift für Zellforschung und Mikroskopische Anatomie 80(3): 413-435

Hummer, M.R., 1986: Mystery rides give residents a world of fun and travel. Provider 12(11): 72-73