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Immunohistochemical detection of p53 protein in human prostatic cancer

, : Immunohistochemical detection of p53 protein in human prostatic cancer. Journal of Urology 152(4): 1297-1301

Tissue sections from 73 radical-prostatectomy specimens were studied immunohistochemically for the presence of p53 protein. In seven specimens numerous tumor cells showed a strong nuclear immunostaining. An additional 27 revealed a more discrete and focal accumulation of p53 protein. Comparison of the pathologic characteristics of the p53-negative and -positive groups showed that the presence of p53 protein closely correlated with more advanced tumor stages (p < 0.00001), with higher primary (p = 0.0004), combined (p < 0.0001) and worst (p < 0.0001) Gleason grades, and with larger total (p = 0.0001) and high-grade (p < 0.0001) tumor volumes. No staining was found in areas of benign hyperplasia or in well-differentiated tumor zones. Our results suggest that the accumulation of p53 protein to immunohistochemically detectable concentrations is not a feature of low-grade cancer. This finding implies that abnormal p53 accumulation might be involved in the process of prostatic cancer progression.


PMID: 8072122

Other references

L.Quellec, Jean Loic, 1999: Repartition de la grande faune sauvage dans le nord de l'Afrique durant l'Holocene. Anthropologie Paris 103(1): 161-176

Loof P.A.A.; Luc M., 1990: A revised polytomous key for the identification of species of the genus xiphinema cobb 1913 nematoda longidoridae with exclusion of the xiphinema americanum group. The species of the genus Xiphinema Cobb, 1913 are listed and their current status is indicated. A revised polytomous key to the 172 valid species (excluding the X. americanum-group) is presented. Because of the very large number of species the key...

Owings, R.S., 1955: Pinworms and oxytetracycline; some of the symptoms before treatment. Oxytetracycline (terramycin) was administered in four equally divided daily doses to cases with Enterobius vermicularis, for a four-day period at the daily rate of 0.5 gm. for those under five years and 1 gm. for those five to twelve years old. Pe...

Brignoli, PM., 1973: Note sulla morfologia dei genitali degli Schizomidi e diagnosi preliminari di due nuove specie del Messico. (Arachnida.Schizomida). Fragmenta Entomologica, 91: 1-9

Saxena, P., 1980: Amylase activity in the midgut of Gryllotalpa africana Orthoptera Grylloidea. National Academy Science Letters (India): 312: 369-372

Beatty, W.W.; Orbelo, D.M.; Sorocco, K.H.; Ross, E.D., 2003: Comprehension of affective prosody in multiple sclerosis. Deficits in cognition have been repeatedly documented in patients with multiple sclerosis (MS), but their ability to comprehend emotional information has received little study. Forty-seven patients with MS and 19 demographic controls received the...

Dominguez, O.J., 2002: Prehospital rounds. The quick stop. The coroner's post-mortem examination revealed a tom aorta. This case illustrates that although a patient may appear stable, a major catastrophic event may nonetheless be taking place. How many times have we responded to MVAs similar to the o...

Calles Ramirez, A.; Hierro Orozco, S., 1967: Clinical experience with a new synthetic steroid in dermatology. Medico [Mexico] 16(11): 68-70

Greene, B.M., 1986: Diethylcarbamazine. The activity, clinical pharmacology, adverse effects, drug interaction, clinical uses and dosing of diethylcarbamazine are discussed.

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