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Immunohistochemical detection of ras p21 oncoprotein in undifferentiated and well-differentiated epithelial carcinomas of the human ovary

, : Immunohistochemical detection of ras p21 oncoprotein in undifferentiated and well-differentiated epithelial carcinomas of the human ovary. Anticancer Research 15(6b): 2847-2850

Expression of ras p21 oncoproteins in human ovarian carcinomas was examined immunohistochemically by using a monoclonal antibody (clone RAS 10) with respect to the degree of their histological differentiation. To achieve this, the intensity of staining for the protein was compared between undifferentiated and well differentiated carcinomas, i.e. extreme subtypes of common epithelial carcinomas. The former was composed of 8 "solid" carcinomas and the latter, 11 serous, 8 mucinous, 4 endometrioid and 4 clear cell carcinomas. All the cases examined, including both undifferentiated and well-differentiated carcinomas, showed a positive reaction to this antibody. Staining intensity and the number of positive cells somewhat varied among the cases. Additionally, 2 cases of ovarian epithelial tumors of low malignant potential(I,MP) were stained with this antibody. Both the cases were positive, but the number of positive cells seemed to be rather less than that found in the carcinoma groups. Thus, no differences in ras p21 expression were observed between the cases examined in spite of the differences in the degree of differentiation of the epithelial ovarian carcinomas. However, the possibility remained that the number of positive cells could be an indicator of malignant potential, enabling us to distinguish LMPs from carcinomas. Thus immuodetection of ras p21 could not provide an additional means for the histological differentiation of ovarian cancer, although the evaluation of basement membrane integrity and cell proliferation kinetics as reported previously was useful in differential diagnosis and in understanding the biology of ovarian undifferentiated carcinomas.


PMID: 8669877

Other references

Ciampi, L.; Forster, O.; Haefely, H.R.; Knauseder, F., 1996: Enzymatic treatment of wool. Official Gazette of the United States Patent & Trademark Office Patents 1187(4): 2810, June 25

D.Palma, L., 1976: Intradural lumbar disc hernia. Report of two cases. Penetration of disc tissue inside the dural sac in the lumbar region ("intradural disc hernia") is a rare occurrence. Two cases are described which presented as multi-root syndromes of the cauda equina. Some clinical aspects are discusse...

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Fishman, S., 1982: The history of childhood sexuality. Journal of Contemporary History 17(2): 269-283

Capaccioli, S.; Paluch, M.; Prevosto, D.; Wang, L-Min.; Ngai, K.L., 2012: Many-Body Nature of Relaxation Processes in Glass-Forming Systems. Most glass-forming systems are composed of basic units interacting with each other with a nontrivial anharmonic potential. Naturally, relaxation and diffusion in glass formers is a many-body problem. Results from recent experimental studies are pr...

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Welzel P., 1982: Optically active glycerol derivatives from 1 3r 4 6r di o benzylidene d mannitol the 1st structural analogs of moenomycin a. Angewandte Chemie International Edition In English: 137-138

Ebata, M., 1968: Current educational system with dire need for revision. Statement by the administrator of a nursing school. Japanese Journal of Nurses' Education 9(7): 25-27

Webb, G.C., 1961: Keys to the genera of the African termites, adapted from Revision der Termiten Afrikas Sjostedt, 1925. Unknown

Abati A.; Wisoff J.; Budzilovich G.; Epstein F., 1987: Pediatric cerebellar medulloblastomas prognostic implications of histologic features. Laboratory Investigation 56(1): 1A