+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of sialosyl-Tn antigen in carcinoma of the prostate

, : Immunohistochemical detection of sialosyl-Tn antigen in carcinoma of the prostate. British Journal Of Urology. 80(3): 456-459

Objective. To investigate the expression of sialosyl-Tn antigen (STn) in human benign and malignant prostate. Materials and methods. The expression of STn was investigated immunohistochemically in formalin-fixed and paraffin-embedded tissue specimens from 56 patients with primary prostatic adenocarcinoma (median age 74.3 years, range 47-89) and 20 patients with benign prostatic hyperplasia (median age 73.4 years, range 60-87). Results. STn was expressed in only three (4%) of the 20 hyperplastic glands and the benign areas adjacent to the 54 carcinomas; by contrast, STn was expressed in 34 (61%) of the 56 carcinomas. The frequency of STn positivity was much higher in well-differentiated carcinomas than in those poorly differentiated. Conclusion. STn is expressed with malignant transformation of the prostatic epithelial cells and immunohistochemical methods using commercially available STn monoclonal antibody may be useful as an adjunct for distinguishing carcinoma from benign tissue.


PMID: 9313667

DOI: 10.1046/j.1464-410x.1997.00306.x

Other references

Jurevicius, J.; Fischmeister, R., 2001: Mitochondrial oxidative phosphorylation regulates the activity of cardiac L-type Ca2+-channels. Biophysical Journal 80(1 Part 2): 196a, January

Seki, S.M.; Stevenson, M.; Rosen, A.M.; Arandjelovic, S.; Gemta, L.; Bullock, T.N.J.; Gaultier, A., 2017: Lineage-Specific Metabolic Properties and Vulnerabilities of T Cells in the Demyelinating Central Nervous System. Multiple sclerosis (MS) is a disease that is characterized by immune-mediated destruction of CNS myelin. Current MS therapies aim to block peripheral immune cells from entering the CNS. Although these treatments limit new inflammatory activity in...

Poulaki, V.; Mitsiades, C.S.; Kotoula, V.; Negri, J.; McMillin, D.; Miller, J.W.; Mitsiades, N., 2007: The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro. novel class of antitumor agents, for the treatment of retinoblastoma. The proteasome inhibitor bortezomib (PS-341, Velcade; Millennium Pharmaceuticals, Cambridge, MA), approved by the US Food and Drug Administration for the treatment of multiple m...

Moriarity, J., L.,. Jr.;; Steinberg, G., K., 1995: Surgical obliteration for vein of galen malformation: A case report. BACKGROUND: Vein of Galen aneurysm is a relatively rare vascular malformation, often resulting in high morbidity or mortality. Outcome is particularly poor in the neonatal population. METHODS: We report staged surgical treatment of a vein of Galen...

Bender, J.S.; Ratner, L.E.; Magnuson, T.H.; Smith Meek, M.A.; Smith, G.W., 1996: General surgery complications following renal transplantation. Gastroenterology 110(4 SUPPL ): A1374

Nishi, S.; Imai, N.; Yoshida, K.; Ito, Y.; Saeki, T., 2012: Clinicopathological findings of immunoglobulin G4-related kidney disease. Immunoglobulin (Ig) G4-related kidney disease characterizing tubulointerstitial nephritis (TIN) is an organ complication recognized in IgG4-related systemic diseases that has some unique aspects compared to other types of TIN. TIN lesions in the k...

Girotti, M.J.; Menkes, E.; MacDonald, J.W.; Hong, K.; Patterson, A.; Todd, T.R., 1984: Effects of immunization on cardiopulmonary alterations of gram-negative endotoxemia. We studied the effects of an infusion of Serratia marcescens endotoxin on hemodynamic function, white blood cells, platelets, and the plasma levels of thromboxane B2 (TXB2) and 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) in awake monitored sh...

Miller, D.; Walker, M.C.; Friedman, D., 1989: Use of a holding technique to control the violent behavior of seriously disturbed adolescents. Therapeutic holding is a treatment technique in which a violent patient is physically contained by people rather than by mechanical or chemical restraints or seclusion. Episodes of therapeutic holding that took place on an inpatient adolescent psy...

Hanzlicek, L., 1963: Present knowledge on humoral action of psychotropic drugs. Activitas Nerv Superior 5(1): 74-93

Ramanan, S., 2017: Distinct Neural Networks Support Autobiographical and Episodic Remembering. Journal of Neuroscience 37(23): 5591-5593